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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Ambient air pollution and diabetes: A systematic review and meta-analysis.
Environ. Res. 180:108817 (2020)
Background: Air pollutants are suggested to be related to type 2 diabetes (T2D). Since several high quality papers on air pollutants and T2D have been published beyond the last reviews, an extended systematic review is highly warranted. We review epidemiological studies to quantify the association between air pollutants and T2D, and to answer if diabetes patients are more vulnerable to air pollutants.Methods: We systematically reviewed the databases of PubMed and Web of Science based on the guidelines of the Preferred Reporting Items for Systematic review and Meta-analysis (PRISMA). We calculated odds ratios (OR) or hazard ratios (HR) and their 95% confidence intervals (CI) to assess the strength of the associations between air pollutants [e.g., particulate matter with diameter <= 2.5 mu m (PM2.5), particulate matter with diameter <= 10 mu m (PM10), and nitrogen dioxide (NO2)] and T2D. We evaluated the quality and risk of bias of the included studies and graded the credibility of the pooled evidence using several recommended tools. We also performed sensitivity analysis, meta-regression analysis, and publication bias test.Results: Out of 716 articles identified, 86 were used for this review and meta-analysis. Meta-analyses showed significant associations of PM2.5 with T2D incidence (11 studies; HR = 1.10, 95% CI = 1.04-1.17 per 10 mu g/m(3) increment; I-2 = 74.4%) and prevalence (11 studies; OR = 1.08; 95% CI = 1.04-1.12 per 10 mu g/m(3) increment; I-2 = 84.3%), of PMDD with T2D prevalence (6 studies; OR = 1.10; 95% CI = 1.03-1.17 per 10 mu g/m(3) increment; I-2 = 89.5%) and incidence (6 studies; HR = 1.11; 95% CI = 1.00-1.22 per mu g/m(3) increment; I-2 = 70.6%), and of NO2 with T2D prevalence (11 studies; OR = 1.07; 95% CI = 1.04-1.11 per 10 mu g/m(3) increment; I-2 = 91.1%). The majority of studies on glucose-homoeostasis markers also showed increased risks with higher air pollutants levels, but the studies were too heterogeneous for meta-analysis. Overall, patients with diabetes might be more vulnerable to PM.Conclusions: Recent publications strengthened the evidence for adverse effects of ambient air pollutants exposure (especially for PM) on T2D and that diabetic patients might be more vulnerable to air pollutants exposure.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Particulate Matter ; Gaseous Pollutant ; Type 2 Diabetes ; Gestational Diabetes ; Mortality; Long-term Exposure; Fine Particulate Matter; Global Burden; Insulin-resistance; Susceptibility Factors; Large Cohort; Lung-cancer; Risk; Association; Mellitus
ISSN (print) / ISBN
0013-9351
e-ISSN
1096-0953
Zeitschrift
Environmental Research
Quellenangaben
Band: 180,
Artikelnummer: 108817
Verlag
Elsevier
Verlagsort
San Diego, Calif.
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed