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Psycharakis, S.E.* ; Liapis, E. ; Zacharopoulos, A.* ; Oraiopoulou, M.E.* ; Aivalioti, C.* ; Sakkalis, V.* ; Papamatheakis, J.* ; Ripoll, J.* ; Zacharakis, G.*

High resolution 3D imaging of primary and secondary tumor spheroids using multicolor multi-angle Light Sheet Fluorescence Microscopy (LSFM).

Proc. SPIE 11076, DOI: 10.1117/12.2527214 (2019)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Breast cancer and Glioblastoma brain cancer are aggressive malignancies with poor prognosis. In this study primary Glioblastoma and secondary breast cancer spheroids are formed and treated with the well-known Temozolomide and Doxorubicin chemotherapeutics, respectively. A custom multi-angle Light Sheet Fluorescence Microscope is employed for high resolution imaging of both cancer cell spheroids. Such a technique is successful in realizing pre-clinical drug screening, while enables the discrimination among physiologic tumor parameters. LSFM technique, parameters and method followed are also presented.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Breast Cancer ; Drug Screening And Individualized Therapy ; Glioblastoma Brain Cancer ; Light Sheet Fluorescence Microscopy (lsfm) ; Multicellular Tumor Spheroids (mcts)
ISSN (print) / ISBN 0277-786X
e-ISSN 1996-756X
Zeitschrift Proceedings of SPIE
Quellenangaben Band: 11076 Heft: , Seiten: , Artikelnummer: , Supplement: ,
Verlag SPIE
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)