Breast cancer and Glioblastoma brain cancer are aggressive malignancies with poor prognosis. In this study primary Glioblastoma and secondary breast cancer spheroids are formed and treated with the well-known Temozolomide and Doxorubicin chemotherapeutics, respectively. A custom multi-angle Light Sheet Fluorescence Microscope is employed for high resolution imaging of both cancer cell spheroids. Such a technique is successful in realizing pre-clinical drug screening, while enables the discrimination among physiologic tumor parameters. LSFM technique, parameters and method followed are also presented.
Impact Factor
Scopus SNIP
Web of Science Times Cited
Scopus Cited By
Altmetric
0.000
0.394
0
0
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
PublikationstypArtikel: Journalartikel
DokumenttypWissenschaftlicher Artikel
Typ der Hochschulschrift
Herausgeber
SchlagwörterBreast Cancer ; Drug Screening And Individualized Therapy ; Glioblastoma Brain Cancer ; Light Sheet Fluorescence Microscopy (lsfm) ; Multicellular Tumor Spheroids (mcts)