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Pawliczek, D. ; Dalke, C. ; Fuchs, H. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Graw, J. ; Amarie, O.V.

Spectral domain - Optical coherence tomography (SD-OCT) as a monitoring tool for alterations in mouse lenses.

Exp. Eye Res. 190:107871 (2020)
Postprint Forschungsdaten DOI PMC
Open Access Green
The eye lens displays a variety of phenotypes in the wake of genetic modifications or environmental influences. Therefore, a high-resolution in vivo imaging method for the lens is desirable. Optical coherence tomography (OCT) has become a powerful imaging tool in ophthalmology, especially for retinal imaging in small animal models such as mice. Here, we demonstrate an optimized approach specifically for anterior eye segment imaging with spectral domain OCT (SD-OCT) on several known murine lens cataract mutants. Scheimpflug and histological section images on the same eye were used in parallel to assess the observed pathologies. With SD-OCT images, we obtained detailed information about the different alterations from the anterior to the posterior pole of the lens. This capability makes OCT a valuable high-resolution imaging modality for the anterior eye segment in mouse.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Mouse ; Eye Lens ; Cataracts ; Oct ; Scheimpflug Imaging; Anterior Segment; Scheimpflug System; In-vivo; Eye; Mutation; Leads
Sprache englisch
Veröffentlichungsjahr 2020
Prepublished im Jahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 0014-4835
e-ISSN 1096-0007
Zeitschrift Experimental Eye Research
Quellenangaben Band: 190, Heft: , Seiten: , Artikelnummer: 107871 Supplement: ,
Verlag Elsevier
Verlagsort 24-28 Oval Rd, London Nw1 7dx, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
Institute of Developmental Genetics (IDG)
POF Topic(s) 30201 - Metabolic Health
30204 - Cell Programming and Repair
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500692-001
G-500500-002
G-500600-001
DOI 10.1016/j.exer.2019.107871
WOS ID WOS:000508286600030
Scopus ID 85075263940
PubMed ID 31751552
Erfassungsdatum 2019-11-25
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