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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Assessment of copper, iron, zinc and manganese status and speciation in patients with Parkinson's disease: A pilot study.
J. Trace Elem. Med. Biol. 59:126423 (2020)
Background: The objective of this pilot study was to assess iron (Fe), copper (Cu), zinc (Zn), and manganese (Mn) status (hair, serum, and urine) and speciation (serum) in Parkinson's disease (PD) patients.Methods: A pilot study involving a total of 27 subjects (13 PD patients, 14 controls) was performed. Serum, urine, and hair metal content was assessed using ICP-MS. Speciation analysis of Cu, Zn, Fe, and Mn was performed using a hybrid HPLC-ICP-MS system.Results: Group comparisons did not reveal any significant group difference in serum Cu, Zn, Fe, and Mn total metal level between PD patients and controls. Speciation analysis revealed a significant decrease in Cu/ceruloplasmin copper in association with elevation of low-molecular weight species (amino acids)-bound copper. It is proposed that in PD, binding of Cu(II) ions to ceruloplasmin is reduced and free copper ions coordinate with low molecular weight ligands. The level of Mn-albumin complexes in PD patients was more than 4-fold higher as compared to the respective value in the control group. The observed difference may be considered as a marker of redistribution between high and low molecular weight ligands.Conclusions: Metal speciation is significantly affected in serum of PD-patients. These findings are indicative of the potential role of metal metabolism and PD pathogenesis, although the exact mechanisms of such associations require further detailed studies.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Parkinson' Disease ; Iron ; Copper ; Manganese ; Speciation Analysis; Neurodegenerative Diseases; Cerebrospinal-fluid; Citrate Complexes; Human Serum; Protein Aggregation; Alzheimers-disease; Crystal-structures; Oxidative Stress; Amino-acids; Ceruloplasmin
ISSN (print) / ISBN
0946-672X
e-ISSN
1878-3252
Quellenangaben
Band: 59,
Artikelnummer: 126423
Verlag
Urban & Fischer
Verlagsort
Hackerbrucke 6, 80335 Munich, Germany
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Research Unit Analytical BioGeoChemistry (BGC)