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Wong, P. ; Frishman, D.

Fold designability, distribution and disease.

PLoS Comput. Biol. 2, 392-402:e40 (2006)
Verlagsversion Volltext DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Fold designability has been estimated by the number of families contained in that fold. Here, we show that among orthologous proteins, sequence divergence is higher for folds with greater numbers of families. Folds with greater numbers of families also tend to have families that appear more often in the proteome and greater promiscuity ( the number of unique "partner'' folds that the fold is found with within the same protein). We also find that many diseaserelated proteins have folds with relatively few families. In particular, a number of these proteins are associated with diseases occurring at high frequency. These results suggest that family counts reflect how certain structures are distributed in nature and is an important characteristic associated with many human diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter HUMAN GENETIC-DISEASE; PRIMATE COLOR-VISION; PROTEIN EVOLUTION; HUMAN GENOME; NATURAL-SELECTION; MOLECULAR-BASIS; SEQUENCE SPACE; DATABASE; RECOMBINATION; MUTATIONS
ISSN (print) / ISBN 1553-734X
e-ISSN 1553-7358
Zeitschrift PLoS Computational Biology
Quellenangaben Band: 2, Heft: 5, Seiten: 392-402, Artikelnummer: e40 Supplement: ,
Verlag Public Library of Science (PLoS)
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Bioinformatics and Systems Biology (IBIS)