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Schnabel, E. ; Schoefer, Y. ; Chen, C.M. ; Schäfer, T. ; Behrendt, H.* ; Ring, J. ; Wichmann, H.-E. ; Heinrich, J.

Sensitization to contact allergens and bronchial hyper-responsiveness.

Contact Dermatitis 63, 157-163 (2010)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
BACKGROUND: Exposure to contact allergens and specific allergic sensitization to them are common, but possible related health effects have been rarely studied. OBJECTIVES: We aimed to analyse possible associations between contact sensitization to nickel sulfate and fragrance mix I and lung function parameters or bronchial hyper-responsiveness. METHODS: Within a population-based study in Augsburg, 1052 adults performed lung function tests, including forced expiratory volume in 1 second (FEV(1)), forced vital capacity (FVC) and bronchial hyper-responsiveness (BHR). Patch tests were performed, and information was assessed by medical examinations and interviews. Logistic regression models were applied to study associations between contact allergies and lung function parameters. RESULTS: Women were sensitized significantly more often than men to nickel [odds ratio (OR) 3.97, 95% confidence interval (CI) 2.50-6.29] and fragrance mix I (OR 2.28, 95% CI 1.50-3.46). Patch test results for nickel and fragrance mix I did not influence mean FEV(1) and FVC % predicted values. However, in women, a higher rate of BHR was associated with positive patch test reactions to fragrance mix I (OR 2.24, 95% CI 1.11-4.52). CONCLUSIONS: Contact sensitization to fragrance mix I is associated with a higher rate of BHR in women. Thus, in women with contact allergy to fragrances, airway obstruction should be considered as a possible co-morbidity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Allergic contact dermatitis; Bronchial hyper-responsiveness; Fragrance; Lung function; Nickel
ISSN (print) / ISBN 0105-1873
e-ISSN 1600-0536
Zeitschrift Contact Dermatitis
Quellenangaben Band: 63, Heft: 3, Seiten: 157-163 Artikelnummer: , Supplement: ,
Verlag Wiley
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)