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Hadrup, N.* ; Saber, A.T.* ; Kyjovska, Z.O.* ; Jacobsen, N.R.* ; Vippola, M.* ; Sarlin, E.* ; Ding, Y. ; Schmid, O. ; Wallin, H.* ; Jensen, K.A.* ; Vogel, U.*

Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials: Inflammation and DNA strand breaks.

Environ. Toxicol. Pharmacol. 74:103303 (2020)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 nanoparticles. Mice were dosed 14, 43 or 128 mu g by intratracheal instillation. Recovery periods were 1, 3, or 28 days. Inflammation neutrophil influx into bronchoalveolar lavage (BAL) fluid - occurred for Fe2O3 rods (1 day), ZnFe2O4 (1, 3 days), NiFe2O4 (1, 3, 28 days), Fe2O3 (28 days) and NiZnFe4O8 (28 days). Conversion of mass-dose into specific surface-area-dose showed that inflammation correlated with deposited surface area and consequently, all these nanomaterials belong to the so-called low-solubility, low-toxicity class. Increased levels of DNA strand breaks were observed for both Fe2O3 particles and rods, in BAL cells three days post-exposure. To our knowledge, this is, besides magnetite (Fe3O4), the first study of the pulmonary toxicity of MFe2O4 spinel nanomaterials.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Nanomaterial ; Iron ; Nickel ; Zinc ; Pulmonary ; Metal Oxides; Acute-phase Response; Zinc-oxide Nanoparticles; Gene-expression Changes; In-vitro Cytotoxicity; Carbon-black; Physicochemical Properties; Ferric-oxide; Worker Exposure; Inhalation; Particles
Sprache englisch
Veröffentlichungsjahr 2020
Prepublished im Jahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 1382-6689
e-ISSN 1872-7077
Zeitschrift Environmental Toxicology and Pharmacology
Quellenangaben Band: 74, Heft: , Seiten: , Artikelnummer: 103303 Supplement: ,
Verlag Elsevier
Verlagsort Radarweg 29, 1043 Nx Amsterdam, Netherlands
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-505000-008
DOI 10.1016/j.etap.2019.103303
WOS ID WOS:000514007200009
Scopus ID 85076229991
PubMed ID 31794919
Erfassungsdatum 2020-01-28
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