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Hadrup, N.* ; Saber, A.T.* ; Kyjovska, Z.O.* ; Jacobsen, N.R.* ; Vippola, M.* ; Sarlin, E.* ; Ding, Y. ; Schmid, O. ; Wallin, H.* ; Jensen, K.A.* ; Vogel, U.*

Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials: Inflammation and DNA strand breaks.

Environ. Toxicol. Pharmacol. 74:103303 (2020)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 nanoparticles. Mice were dosed 14, 43 or 128 mu g by intratracheal instillation. Recovery periods were 1, 3, or 28 days. Inflammation neutrophil influx into bronchoalveolar lavage (BAL) fluid - occurred for Fe2O3 rods (1 day), ZnFe2O4 (1, 3 days), NiFe2O4 (1, 3, 28 days), Fe2O3 (28 days) and NiZnFe4O8 (28 days). Conversion of mass-dose into specific surface-area-dose showed that inflammation correlated with deposited surface area and consequently, all these nanomaterials belong to the so-called low-solubility, low-toxicity class. Increased levels of DNA strand breaks were observed for both Fe2O3 particles and rods, in BAL cells three days post-exposure. To our knowledge, this is, besides magnetite (Fe3O4), the first study of the pulmonary toxicity of MFe2O4 spinel nanomaterials.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Nanomaterial ; Iron ; Nickel ; Zinc ; Pulmonary ; Metal Oxides; Acute-phase Response; Zinc-oxide Nanoparticles; Gene-expression Changes; In-vitro Cytotoxicity; Carbon-black; Physicochemical Properties; Ferric-oxide; Worker Exposure; Inhalation; Particles
ISSN (print) / ISBN 1382-6689
e-ISSN 1872-7077
Zeitschrift Environmental Toxicology and Pharmacology
Quellenangaben Band: 74, Heft: , Seiten: , Artikelnummer: 103303 Supplement: ,
Verlag Elsevier
Verlagsort Radarweg 29, 1043 Nx Amsterdam, Netherlands
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Lung Health and Immunity (LHI)