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Erlic, Z.* ; Kurlbaum, M.* ; Deutschbein, T.* ; Noelting, S.* ; Prejbisz, A.* ; Timmers, H.J.* ; Richter, S.* ; Prehn, C. ; Weismann, D.* ; Adamski, J. ; Januszewicz, A.* ; Reincke, M.* ; Fassnacht, M.* ; Robledo, M.* ; Eisenhofer, G.* ; Beuschlein, F.* ; Kroiss, M.*

Metabolic impact of pheochromocytoma/ paraganglioma: Targeted metabolomics in patients before and after tumor removal.

Eur. J. Endocrinol. 181, 647-657 (2019)
Verlagsversion DOI PMC
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Objective: Excess catecholamine release by pheochromocytomas and paragang liomas (PPGL) leads to characteristic clinical features and increased morbidity and mortality. The in fluence of PPGLs on metabolism is ill described but may impact diagnosis and management. The objective of this study wa s to systematically and quantitatively study PPGL-induced metabolic changes at a systems level. Design: Targeted metabolomics by liquid chromatography-tandem mass spe ctrometry of plasma specimens in a clinically well-characterized prospective cohort study. Methods: Analyses of metabolic profiles of plasma specimens from 56 pros pectively enrolled and clinically well-characterized patients (23 males, 33 females) with catecholamin e-producing PPGL before and after surgery, as well as measurement of 24-h urinary catecholamine using LC-MS/MS. Results: From 127 analyzed metabolites, 15 were identified with significa nt changes before and after surgery: Five amino acids/biogenic amines (creatinine, histidine, ornithine, sarcosine, tyrosine) and one glycerophospholipid (PCaeC34:2) with increased concentrations and six glycerophospholipids (PCaaC38:1, PCaaC42:0, PCaeC40:2, PCaeC42:5, PCaeC44:5, PCaeC44:6), two sphingomyelins (SMC24:1, SMC26:1) and hexose with decreased levels after surgery. Patients with a noradrenergic tumor phenotype had more pronounced alterations compared to those with an adrenergic tumor phenotype. Weak, but significant correlation s for 8 of these 15 metabolites with total urine catecholamine levels were identified. Conclusions: This first large prospective metabolomics analysis of PPGL pati ents demonstrates broad metabolic consequences of catecholamine excess. Robust impact on lipid an d amino acid metabolism may contribute to increased morbidity of PPGL patients.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Oxidative Stress; Inflammation; Histidine; Endocrine; Diagnosis; Markers
Sprache englisch
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 0804-4643
e-ISSN 1479-683X
Zeitschrift European Journal of Endocrinology
Quellenangaben Band: 181, Heft: 6, Seiten: 647-657 Artikelnummer: , Supplement: ,
Verlag BioScientifica
Verlagsort Starling House, 1600 Bristol Parkway N, Bristol, England
Begutachtungsstatus Peer reviewed
Institut(e) Molekulare Endokrinologie und Metabolismus (MEM)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-505600-003
DOI 10.1530/EJE-19-0589
WOS ID WOS:000500256000014
Scopus ID 85076511881
PubMed ID 31614337
Erfassungsdatum 2019-12-23
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