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Sassy, T. ; Breiter, N.* ; Sroku, R. ; Ernst, H.*

Acute and chronic effects of rat colon after photodynamic therapy and radiotherapy - A comparative study.

Proc. SPIE 2078, 453-457 (1994)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
After clinical photodynamic therapy (PDT) and radiotherapy (RT) of the colon carcinoma acute and late damages on adjacent normal tissue were seen. Therefore it was the aim of this experimental study to investigate these damages on normal colon tissue of rats after PDT in comparison with RT. For PDT the rats got Photofrin® (5 mg/kg bw, i.v.) 24 h prior to the laser light illumination (630 nm, 100 mW/cm2, 20-100 J/cm2) at 20-50 mm proximal from the anus. In the RT-group a localized 300 kV x-irradiation with 23 Gy of a 24 mm long segment of the rat colon, 26-50 mm proximal from the anus, was performed. Within the first hours after PDT the endoscopic examination showed a severe acute damage. The histopathological examination showed that the acute ulceration depends on the energy density applied within the first three days. Animals receiving a synthetic diet before and during the PDT treatment survived the acute phase and showed no late effects. After x-irradiation the acute damage of the mucosa occurred in the second week post irradiation and could be observed by endoscopy. After 4 to 10 weeks late damage started with ulceration and colon obstruction. All animals receiving the synthetic diet after x-irradiation survived as long as the diet was maintained. When the diet was changed to the standard pellets more than 90% of the rats developed a progressive large bowel obstruction. This study indicates different progresses of acute effects after PDT and RT, respectively. Late damages were observed only by RT in contrast to PDT. Synthetic diet prevents acute damages after PDT. However, the synthetic diet after RT can prevent the late damage for the duration of the diet administration.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 0277-786X
e-ISSN 1996-756X
Zeitschrift Proceedings of SPIE
Quellenangaben Band: 2078, Heft: , Seiten: 453-457 Artikelnummer: , Supplement: ,
Verlag SPIE
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Departments & Institutes