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Ahmed, A.T.* ; MahmoudianDehkordi, S.* ; Bhattacharyya, S.* ; Arnold, M. ; Liu, D.* ; Neavin, D.* ; Moseley, M.A.* ; Thompson, J.W.* ; Williams, L.S.J.* ; Louie, G.* ; Skime, M.K.* ; Wang, L.* ; Riva-Posse, P.* ; McDonald, W.M.* ; Bobo, W.V.* ; Craighead, W.E.* ; Krishnan, R.* ; Weinshilboum, R.M.* ; Dunlop, B.W.* ; Millington, D.S.* ; Rush, A.J.* ; Frye, M.A.* ; Kaddurah-Daouk, R.*

Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes.

J. Affect. Disord. 264, 90-97 (2020)
Postprint Forschungsdaten DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Background: Acylcarnitines have important functions in mitochondrial energetics and beta-oxidation, and have been implicated to play a significant role in metabolic functions of the brain. This retrospective study examined whether plasma acylcarnitine profiles can help biochemically distinguish the three phenotypic subtypes of major depressive disorder (MDD): core depression (CD+), anxious depression (ANX+), and neurovegetative symptoms of melancholia (NVSM+).Methods: Depressed outpatients (n = 240) from the Mayo Clinic Pharmacogenomics Research Network were treated with citalopram or escitalopram for eight weeks. Plasma samples collected at baseline and after eight weeks of treatment with citalopram or escitalopram were profiled for short-, medium- and long-chain acylcarnitine levels using AbsoluteIDQ (R) p180-Kit and LC-MS. Linear mixed effects models were used to examine whether acylcarnitine levels discriminated the clinical phenotypes at baseline or eight weeks post-treatment, and whether temporal changes in acylcarnitine profiles differed between groups.Results: Compared to ANX+, CD+ and NVSM+ had significantly lower concentrations of short- and long-chain acylcarnitines at both baseline and week 8. In NVSM+, the medium- and long-chain acylcarnitines were also significantly lower in NVSM+ compared to ANX+. Short-chain acylcarnitine levels increased significantly from baseline to week 8 in CD+ and ANX+, whereas medium- and long-chain acylcarnitines significantly decreased in CD+ and NVSM+.Conclusions: In depressed patients treated with SSRIs, beta-oxidation and mitochondrial energetics as evaluated by levels and changes in acylcarnitines may provide the biochemical basis of the clinical heterogeneity of MDD, especially when combined with clinical characteristics.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Metabolomics ; Acylcarnitines ; P180 ; Depression ; Antidepressants ; Phenotypes; Mitochondrial-function; Carnitine; Disease; Genome; Dna
ISSN (print) / ISBN 0165-0327
e-ISSN 1573-2517
Zeitschrift Journal of Affective Disorders
Quellenangaben Band: 264, Heft: , Seiten: 90-97 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Radarweg 29, 1043 Nx Amsterdam, Netherlands
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)