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Hattwell, J.P.N.* ; Hastings, J.* ; Casanueva, O.* ; Schirra, H.J.* ; Witting, M.

Using genome-scale metabolic networks for analysis, visualization, and integration of targeted metabolomics data.

In: Computational Methods and Data Analysis for Metabolomics. Berlin [u.a.]: Springer, 2020. 361-386 (Methods Mol. Biol. ; 2104)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Interpretation of metabolomics data in the context of biological pathways is important to gain knowledge about underlying metabolic processes. In this chapter we present methods to analyze genome-scale models (GSMs) and metabolomics data together. This includes reading and mining of GSMs using the SBTab format to retrieve information on genes, reactions, and metabolites. Furthermore, the chapter showcases the generation of metabolic pathway maps using the Escher tool, which can be used for data visualization. Lastly, approaches to constrain flux balance analysis (FBA) by metabolomics data are presented.
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Publikationstyp Artikel: Sammelbandbeitrag/Buchkapitel
Korrespondenzautor
Schlagwörter Analysis ; Integration ; Metabolic Networks ; Metabolomics ; Visualization
ISSN (print) / ISBN 1064-3745
e-ISSN 1940-6029
Bandtitel Computational Methods and Data Analysis for Metabolomics
Zeitschrift Methods in Molecular Biology
Quellenangaben Band: 2104, Heft: , Seiten: 361-386 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Berlin [u.a.]
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Analytical BioGeoChemistry (BGC)