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No association between genetic variants at the GRIN1 gene and bipolar disorder in a Germany sample.
Psychiatr. Genet. 16, 183-184 (2006)
Disturbed glutamatergic neurotransmission has been implicated in the pathogenesis of schizophrenia and bipolar disorder, with the N-methy-D-aspartate receptors being in the focus of research. The NR1 subunit, which is encoded by the gene GRIN1, plays a key role in the functionality of N-methy-D-aspartate receptors. We tested the association between GRIN1 and bipolar disorder in a sample of German descent, consisting of 306 bipolar disorder patients and 319 population-based controls. No significant association was found. In accordance with our recent findings, we hypothesized that restricting case definition to individuals with a history of persecutory delusions might clarify the relationship between bipolar disorder and GRIN1. This stratified analysis did not yield any significant association either. Our results do not support an association of the GRIN1 gene with bipolar disorder in the German population. © 2006 Lippincott Williams & Wilkins.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
bipolar disorder; glutamateric; neurotransmission; GRIN1
ISSN (print) / ISBN
0955-8829
e-ISSN
1473-5873
Zeitschrift
Psychiatric Genetics
Quellenangaben
Band: 16,
Heft: 5,
Seiten: 183-184
Verlag
Lippincott Williams & Wilkins
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Epidemiology (EPI)