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Zambusi, A. ; Ninkovic, J.

Regeneration of the central nervous system-principles from brain regeneration in adult zebrafish.

World J. Stem Cells 12, 8-24 (2020)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Poor recovery of neuronal functions is one of the most common healthcare challenges for patients with different types of brain injuries and/or neurodegenerative diseases. Therapeutic interventions face two major challenges: (1) How to generate neurons de novo to replenish the neuronal loss caused by injuries or neurodegeneration (restorative neurogenesis) and (2) How to prevent or limit the secondary tissue damage caused by long-term accumulation of glial cells, including microglia, at injury site (glial scar). In contrast to mammals, zebrafish have extensive regenerative capacity in numerous vital organs, including the brain, thus making them a valuable model to improve the existing therapeutic approaches for human brain repair. In response to injuries to the central nervous system (CNS), zebrafish have developed specific mechanisms to promote the recovery of the lost tissue architecture and functionality of the damaged CNS. These mechanisms include the activation of a restorative neurogenic program in a specific set of glial cells (ependymoglia) and the resolution of both the glial scar and inflammation, thus enabling proper neuronal specification and survival. In this review, we discuss the cellular and molecular mechanisms underlying the regenerative ability in the adult zebrafish brain and conclude with the potential applicability of these mechanisms in repair of the mammalian CNS.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Zebrafish ; Central Nervous System ; Brain Injury ; Glial Scar ; Regeneration ; Restorative Neurogenesis ; Neural Stem Cells ; Inflammation; Neural Stem-cells; Live Imaging Reveals; Radial Glia; Neuronal Regeneration; Progenitor Cells; In-vivo; Stab Injury; Neurogenesis; Microglia; Inflammation
ISSN (print) / ISBN 1948-0210
e-ISSN 1948-0210
Zeitschrift World journal of stem cells
Quellenangaben Band: 12, Heft: 1, Seiten: 8-24 Artikelnummer: , Supplement: ,
Verlag Beijing Baishideng BioMed Scientific Co.
Verlagsort Beijing, China
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)