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Intravital optoacoustic and ultrasound bio-microscopy reveal radiation-inhibited skull angiogenesis.
Bone 133:115251 (2020)
Angiogenesis is critical in bone development and growth. Dense, large-scale, and multi-layered vascular networks formed by thin-walled sinusoidal vessels perfuse the plate bones and play an important role in bone repair. Yet, the intricate functional morphology of skull microvasculature remains poorly understood as it is difficult to visualize using existing intravital microscopy techniques. Here we introduced an intravital, fully-transcranial imaging approach based on hybrid optoacoustic and ultrasound bio-microscopy for large-scale observations and quantitative analysis of the vascular morphology, angiogenesis, vessel remodeling, and subsurface roughness in murine skulls. Our approach revealed radiation-inhibited angiogenesis in the skull bone. We also observed previously undocumented sinusoidal vascular networks spanning the entire skullcap, thus opening new vistas for studying the complex interactions between calvarial, pial, and cortical vascular systems.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Skull Vasculature ; Radiation ; Optoacoustic Microscopy ; Ultrasound Microscopy ; Bone Angiogenesis ; Image Segmentation ; Quantitative Vasculature Analysis; Bone-marrow; Ionizing-radiation; Cells; Mechanisms; Brain; Veins
ISSN (print) / ISBN
8756-3282
e-ISSN
1873-2763
Quellenangaben
Band: 133,
Artikelnummer: 115251
Verlag
Elsevier
Verlagsort
Ste 800, 230 Park Ave, New York, Ny 10169 Usa
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed