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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Heat shock proteins in cancer.
Ann. NY Acad. Sci. 1113, 192-201 (2007)
Heat shock proteins (Hsps) are highly conserved and inhabit nearly all subcellular locations where they perform a variety of chaperoning functions including folding and unfolding of nascent polypeptides, proteins, transport of proteins, and support of antigen presentation processes. Apart from their intracellular location Hsps with a molecular weight of 70 kDa (Hsp70) also have been found on the plasma membrane of malignantly transformed cells, on virally/bacterial infected cells and in the extracellular space. Depending on their intra- and extracellular location Hsps exert either protection against environmental stress or act as potent stimulators of the immune response. In this review we address the dual function of intracellular and extracellular located small Hsps and members of the Hsp70 family and its immunological consequences for cancer immunity.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
heat shock proteins; adaptive/innate immune response; cancer
ISSN (print) / ISBN
0077-8923
e-ISSN
1749-6632
Zeitschrift
Annals of the New York Academy of Sciences
Quellenangaben
Band: 1113,
Seiten: 192-201
Verlag
New York Academy of Sciences
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
CCG Innate Immunity in Tumor Biology (PATH-KTB)