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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
A role for beta-melanocyte-stimulating hormone in human body-weight regulation.
Cell Metab. 3, 141-146 (2006)
Verlagsversion
DOI
PMC
Pro-opiomelanocortin (POMC) expressing neurons mediate the regulation of orexigenic drive by peripheral hormones such as leptin, cholecystokinin, ghrelin, and insulin. Most research effort has focused on alpha-melanocyte-stimulating hormone (alpha-MSH) as the predominant POMC-derived neuropeptide in the central regulation of human energy balance and body weight. Here we report a missense mutation within the coding region of the POMC-derived peptide beta-MSH (Y5C-beta-MSH) and its association with early-onset human obesity. In vitro and in vivo data as well as postmortem human brain studies indicate that the POMC-derived neuropeptide beta-MSH plays a critical role in the hypothalamic control of body weight in humans.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
1550-4131
e-ISSN
1932-7420
Zeitschrift
Cell Metabolism
Quellenangaben
Band: 3,
Heft: 2,
Seiten: 141-146
Verlag
Elsevier
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Diabetes and Obesity (IDO)