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Bertheau, R.C.* ; Lorbeer, R.* ; Nattenmüller, J.* ; Wintermeyer, E.* ; Machann, J. ; Linkohr, B.* ; Peters, A. ; Bamberg, F.* ; Schlett, C.L.*

Bone marrow fat fraction assessment in regard to physical activity: KORA FF4-3-T MR imaging in a population-based cohort.

Eur. Radiol. 30, 3417-3428 (2020)
Postprint DOI PMC
Open Access Green
Objectives To establish the effect of different degrees and kinds of physical activity on bone marrow fat (BMAT) content at different anatomical locations in a population-based cohort study undergoing whole-body MR imaging. Methods Subjects of the KORA FF4 study without known cardiovascular disease underwent BMAT fat fraction (FF) quantification in L1 and L2 vertebrae and femoral heads/necks (hip) via a 2-point T1-weighted VIBE Dixon sequence. BMAT-FF was calculated as mean value (fat image) divided by mean value (fat + water image). Physical activity was determined by self-assessment questionnaire regarding time spent exercising, non-exercise walking, non-exercise cycling, and job-related physical activity. Results A total of 385 subjects (96% of 400 available; 56 +/- 9.1 years; 58% male) were included in the analysis. Exercise was distributed quite evenly (29% > 2 h/week; 31% 1 h/week (regularly); 15% 1 h/week (irregularly); 26% no physical activity). BMAT-FF was 52.6 +/- 10.2% in L1, 56.2 +/- 10.3% in L2, 87.4 +/- 5.9% in the right hip, and 87.2 +/- 5.9% in the left hip (all p < 0.001). Correlation of BMAT-FF between spine and hip was only moderate (r 0.42 to 0.46). Spinal BMAT-FF, but not hip BMAT-FF, was inversely associated with exercise > 2 h/week (p <= 0.02 vs. p >= 0.35, respectively). These associations remained significant after adjusting for age, gender, waist circumference, and glucose tolerance. No coherent association was found between BMAT-FF and physical activity in the less active groups. Conclusions In our study, exercise was inversely correlated with vertebral BMAT-FF, but not hip BMAT-FF, when exercising for more than 2 h per week. Physical activity seems to affect the spine at least preferentially compared to the hip.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Physical Activity ; Bone Marrow ; Adipose Tissue ; Magnetic Resonance Imaging ; Fat Fraction; Adipose-tissue; Body-composition; Visceral Fat; Bed Rest; Exercise; Age; Accumulation; Obesity; Water; Women
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 0938-7994
e-ISSN 1432-1084
Zeitschrift European Radiology
Quellenangaben Band: 30, Heft: 6, Seiten: 3417-3428 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort One New York Plaza, Suite 4600, New York, Ny, United States
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Epidemiology (EPI)
POF Topic(s) 90000 - German Center for Diabetes Research
30202 - Environmental Health
Forschungsfeld(er) Helmholtz Diabetes Center
Genetics and Epidemiology
PSP-Element(e) G-502400-001
G-504000-006
G-504000-010
G-501900-401
G-504090-001
DOI 10.1007/s00330-019-06612-y
WOS ID WOS:000516314700008
Scopus ID 85080958455
PubMed ID 32086579
Erfassungsdatum 2020-03-25
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