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Karusheva, Y.* ; Kunstein, L.* ; Bierwagen, A.* ; Nowotny, B.* ; Kabisch, S.* ; Groener, J.B.* ; Fleitmann, A.K.* ; Herder, C.* ; Pacini, G.* ; Strassburger, K.* ; Häring, H.-U. ; Nawroth, P.P.* ; Pfeiffer, A.F.H.* ; Burkart, V.* ; Müssig, K.* ; Roden, M.* ; Szendroedi, J.*

An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: A randomized controlled trial.

Nutr. Metab. 15:90 (2018)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Background: Higher dietary intake of fibers and coffee, but lower red meat intake is associated with reduced risk for type 2 diabetes in epidemiological studies. We hypothesized that a calorie-restricted diet, which is high in fiber and coffee, but free of red meat, improves beta-cell function in patients with T2D. Methods: In a randomized parallel-group pilot trial, obese type 2 diabetes patients were randomly allocated to consume either a diet high in cereal fiber and coffee, but free of red meat (n = 17) (L-RISK) or a diet low in fiber, free of coffee but high in red meat (n = 20) (H-RISK) for 8 weeks. Insulin secretion was assessed from glucagon stimulation tests (GST) and mixed-meal tolerance tests (MMTT) before and after dietary intervention. Results: Both diets resulted in comparable reduction of fasting concentrations of insulin (H-RISK -28% vs. L-RISK -32%, bothp < 0.01), C-peptide (H-RISK -26% vs. L-RISK -30%, bothp < 0.01) and blood glucose (H-RISK -6.8%, p < 0.05 vs. L-RISK -10%, p < 0.01). Gastric inhibitory peptide (GIP) secretion increased by 24% after 8 weeks in the L-RISK only (p < 0.01). However, GST and MMTT showed no differences in insulin secretion after intervention. Conclusions: Calorie restriction independent of the intake of fiber, coffee or meat failed to improve beta-cell function, but improved GIP secretion in obese patients with type 2 diabetes. Trial registration: Registration at Clinicaltrials.gov, Identifier number: NCT01409330, Registered 4 August 2011 - Retrospectively registered.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Beta-cell Function ; Calorie Restriction ; Coffee ; Dietary Fiber ; Red Meat
ISSN (print) / ISBN 1743-7075
e-ISSN 1743-7075
Zeitschrift Nutrition & metabolism
Quellenangaben Band: 15, Heft: , Seiten: , Artikelnummer: 90 Supplement: ,
Verlag BioMed Central
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)