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Ovsepian, S.V. ; Jiang, Y.* ; Sardella, T.C.P.* ; Malekzadeh Najafabadi, J. ; Burton, N.C.* ; Yu, X.* ; Ntziachristos, V.

Visualizing cortical response to optogenetic stimulation and sensory inputs using multispectral handheld optoacoustic imaging.

Photoacoustics 17:100153 (2020)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
To date, the vast majority of intra-vital neuroimaging systems applied in clinic and diagnostics is stationary with a rigid scanning element, requires specialized facilities and costly infrastructure. Here, we describe a simple yet radical approach for optoacoustic (photoacoustic) brain imaging in vivo using a light-weight handheld probe. It enables multispectral video-rate visualization of hemoglobin gradient changes in the cortex of adult rats induced by whisker and forelimb sensory inputs, as well as by optogenetic stimulation of intra-cortical connections. With superb penetration and molecular specificity, described here in method holds major promises for future applications in research, routine ambulatory neuroimaging, and diagnostics.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Neuroimaging ; Hemoglobin Gradients ; Brain ; Optogenetic Stimulation ; Photoacoustic ; Handheld Probe ; Barrel Cortex; Tomography Msot; Brain; Feasibility
ISSN (print) / ISBN 2213-5979
Zeitschrift Photoacoustics
Quellenangaben Band: 17, Heft: , Seiten: , Artikelnummer: 100153 Supplement: ,
Verlag Elsevier
Verlagsort Hackerbrucke 6, 80335 Munich, Germany
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)