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Kappler, L.* ; Kollipara, L.* ; Lehmann, R. ; Sickmann, A.*

Investigating the role of mitochondria in type 2 diabetes lessons from lipidomics and proteomics studies of skeletal muscle and liver.

In: Mitochondria in Health and in Sickness. New York: Springer, 2019. 143-182 (Adv. Exp. Med. Biol. ; 1158)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Mitochondrial dysfunction is discussed as a key player in the pathogenesis of type 2 diabetes mellitus (T2Dm), a highly prevalent disease rapidly developing as one of the greatest global health challenges of this century. Data however about the involvement of mitochondria, central hubs in bioenergetic processes, in the disease development are still controversial. Lipid and protein homeostasis are under intense discussion to be crucial for proper mitochondrial function. Consequently proteomics and lipidomics analyses might help to understand how molecular changes in mitochondria translate to alterations in energy transduction as observed in the healthy and metabolic diseases such as T2Dm and other related disorders. Mitochondrial lipids integrated in a tool covering proteomic and functional analyses were up to now rarely investigated, although mitochondria]. lipids might provide a possible lynchpin in the understanding of type 2 diabetes development and thereby prevention. In this chapter state-of-the-art analytical strategies, pre -analytical aspects, potential pitfalls as well as current proteomics and lipidomics-based knowledge about the pathophysiological role of mitochondria in the pathogenesis of type 2 diabetes will be discussed.
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Publikationstyp Artikel: Sammelbandbeitrag/Buchkapitel
Korrespondenzautor
Schlagwörter Type 2 Diabetes ; Mitochondria ; Lipidomics ; Proteomics ; Mass Spectrometry ; Function; Nonalcoholic Fatty Liver; Electron-transport Chain; Top-down Proteomics; Reversed-phase Chromatography; Induced Insulin-resistance; Oxygen Species Production; Protein Import Machinery; Chemical Cross-linking; C-oxidase Activity; Tert-butyl Ether
ISSN (print) / ISBN 0065-2598
Bandtitel Mitochondria in Health and in Sickness
Zeitschrift Advances in Experimental Medicine and Biology
Quellenangaben Band: 1158, Heft: , Seiten: 143-182 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort New York
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)