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Large animal models of diabetes.
In: Animal Models of Diabetes. Berlin [u.a.]: Springer, 2020. 115-134 (Methods Mol. Biol. ; 2128)
Safe and reliable large animal diabetes models are a key prerequisite for advanced preclinical studies on diabetes. Chemical induction is the standard model of diabetes in rodents but is often critiqued in higher animals due to reduced efficacy, relevant side effects, and inadequate mortality rate. In this chapter, we aim to describe both pharmacological and surgical approaches for reproducible and safe diabetes models in minipigs and primates. In addition, genetically modified pig models for diabetes research are described.
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Publikationstyp
Artikel: Sammelbandbeitrag/Buchkapitel
Schlagwörter
Diabetes Induction ; Diabetes Model ; Pancreatectomy ; Pig Model ; Primate Model ; Streptozotocin
ISSN (print) / ISBN
1064-3745
e-ISSN
1940-6029
Bandtitel
Animal Models of Diabetes
Zeitschrift
Methods in Molecular Biology
Quellenangaben
Band: 2128,
Seiten: 115-134
Verlag
Springer
Verlagsort
Berlin [u.a.]
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Pancreatic Islet Research (IPI)