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Munir, S.* ; Basu, A.* ; Maity, P.* ; Krug, L.* ; Haas, P.* ; Jiang, D. ; Strauss, G.* ; Wlaschek, M.* ; Geiger, H.* ; Singh, K.* ; Scharffetter-Kochanek, K.*

TLR4-dependent shaping of the wound site by MSCs accelerates wound healing.

EMBO Rep. 21:e48777 (2020)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
We here address the question whether the unique capacity of mesenchymal stem cells to re-establish tissue homeostasis depends on their potential to sense pathogen-associated molecular pattern and, in consequence, mount an adaptive response in the interest of tissue repair. After injection of MSCs primed with the bacterial wall component LPS into murine wounds, an unexpected acceleration of healing occurs, clearly exceeding that of non-primed MSCs. This correlates with a fundamental reprogramming of the transcriptome in LPS-treated MSCs as deduced from RNAseq analysis and its validation. A network of genes mediating the adaptive response through the Toll-like receptor 4 (TLR4) pathway responsible for neutrophil and macrophage recruitment and their activation profoundly contributes to enhanced wound healing. In fact, injection of LPS-primed MSCs silenced for TLR4 fails to accelerate wound healing. These unprecedented findings hold substantial promise to refine current MSC-based therapies for difficult-to-treat wounds.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Adaptive Transcriptomic Response ; Lps Sensing ; Mesenchymal Stem Cells ; Msc-based Therapy ; Neutrophils ; Wound Healing
ISSN (print) / ISBN 1469-221X
e-ISSN 1469-3178
Zeitschrift EMBO Reports
Quellenangaben Band: 21, Heft: 5, Seiten: , Artikelnummer: e48777 Supplement: ,
Verlag EMBO Press
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Lung Health and Immunity (LHI)