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An ocular glymphatic clearance system removes beta-amyloid from the rodent eye.
Sci. Transl. Med. 12:eaaw3210 (2020)
Despite high metabolic activity, the retina and optic nerve head lack traditional lymphatic drainage. We here identified an ocular glymphatic clearance route for fluid and wastes via the proximal optic nerve in rodents. beta-amyloid (A beta) was cleared from the retina and vitreous via a pathway dependent on glial water channel aquaporin-4 (AQP4) and driven by the ocular-cranial pressure difference. After traversing the lamina barrier, intra-axonal A beta was cleared via the perivenous space and subsequently drained to lymphatic vessels. Light-induced pupil constriction enhanced efflux, whereas atropine or raising intracranial pressure blocked efflux. In two distinct murine models of glaucoma, A. leaked from the eye via defects in the lamina barrier instead of directional axonal efflux. The results suggest that, in rodents, the removal of fluid and metabolites from the intraocular space occurs through a glymphatic pathway that might be impaired in glaucoma.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Optic-nerve Head; Ganglion-cell Degeneration; Intraocular-pressure; Mouse Model; Intracranial-pressure; Lamina-cribrosa; Disc Edema; Glaucoma; Brain; Fluid
ISSN (print) / ISBN
1946-6234
e-ISSN
1946-6242
Zeitschrift
Science Translational Medicine
Quellenangaben
Band: 12,
Heft: 536,
Artikelnummer: eaaw3210
Verlag
American Association for the Advancement of Science (AAAS)
Verlagsort
1200 New York Ave, Nw, Washington, Dc 20005 Usa
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute for Tissue Engineering and Regenerative Medicine (ITERM)