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Hadrup, N.* ; Zhernovkov, V.* ; Jacobsen, N.R.* ; Voss, C. ; Strunz, M. ; Schiller, H. B. ; Halappanavar, S.* ; Poulsen, S.S.* ; Kholodenko, B.* ; Stöger, T. ; Saber, A.T.* ; Vogel, U.*

Acute phase response as a biological mechanism-of-action of (nano)particle-induced cardiovascular disease.

Small 16:1907476 (2020)
Verlagsversion DOI
Open Access Hybrid
Creative Commons Lizenzvertrag
Inhaled nanoparticles constitute a potential health hazard due to their size-dependent lung deposition and large surface to mass ratio. Exposure to high levels contributes to the risk of developing respiratory and cardiovascular diseases, as well as of lung cancer. Particle-induced acute phase response may be an important mechanism of action of particle-induced cardiovascular disease. Here, the authors review new important scientific evidence showing causal relationships between inhalation of particle and nanomaterials, induction of acute phase response, and risk of cardiovascular disease. Particle-induced acute phase response provides a means for risk assessment of particle-induced cardiovascular disease and underscores cardiovascular disease as an occupational disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Atherosclerosis ; Cardiovascular Diseases ; C-reactive Protein ; Nanoparticles ; Occupational Exposure ; Serum Amyloid A; Particulate Air-pollution; C-reactive Protein; Titanium-dioxide Nanoparticles; Reverse Cholesterol Transport; Long-term Exposure; Serum Amyloid-a; Welding Fumes; Physicochemical Properties; Pulmonary Exposure; In-vivo
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 1613-6810
e-ISSN 1613-6829
Zeitschrift Small
Quellenangaben Band: 16, Heft: 21, Seiten: , Artikelnummer: 1907476 Supplement: ,
Verlag Wiley
Verlagsort Postfach 101161, 69451 Weinheim, Germany
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
German Center for Lung Research (DZL)
POF Topic(s) 30202 - Environmental Health
80000 - German Center for Lung Research
Forschungsfeld(er) Lung Research
PSP-Element(e) G-505000-001
G-501800-810
DOI 10.1002/smll.201907476
WOS ID WOS:000522067300001
Scopus ID 85082447115
Erfassungsdatum 2020-04-07
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