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Acute phase response as a biological mechanism-of-action of (nano)particle-induced cardiovascular disease.
Small 16:1907476 (2020)
Inhaled nanoparticles constitute a potential health hazard due to their size-dependent lung deposition and large surface to mass ratio. Exposure to high levels contributes to the risk of developing respiratory and cardiovascular diseases, as well as of lung cancer. Particle-induced acute phase response may be an important mechanism of action of particle-induced cardiovascular disease. Here, the authors review new important scientific evidence showing causal relationships between inhalation of particle and nanomaterials, induction of acute phase response, and risk of cardiovascular disease. Particle-induced acute phase response provides a means for risk assessment of particle-induced cardiovascular disease and underscores cardiovascular disease as an occupational disease.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Atherosclerosis ; Cardiovascular Diseases ; C-reactive Protein ; Nanoparticles ; Occupational Exposure ; Serum Amyloid A; Particulate Air-pollution; C-reactive Protein; Titanium-dioxide Nanoparticles; Reverse Cholesterol Transport; Long-term Exposure; Serum Amyloid-a; Welding Fumes; Physicochemical Properties; Pulmonary Exposure; In-vivo
ISSN (print) / ISBN
1613-6810
e-ISSN
1613-6829
Zeitschrift
Small
Quellenangaben
Band: 16,
Heft: 21,
Artikelnummer: 1907476
Verlag
Wiley
Verlagsort
Postfach 101161, 69451 Weinheim, Germany
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Lung Health and Immunity (LHI)