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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Impact of maternal smoking associated lyso-phosphatidylcholine 20:3 on offspring brain development.
J. Steroid Biochem. Mol. Biol. 199:105591 (2020)
Maternal smoking during pregnancy affects fetal neurological development. Metabolomic studies in the general population suggest that smoking is associated with characteristic metabolic alterations. We investigated the association between the maternal smoking status, the fetal metabolome and head circumference at birth, as a surrogate parameter of brain development. 320 mother/newborn pairs of the Berlin Birth Cohort were investigated. Anthropometric parameters, including head circumference, of newborns of smoking mothers, former smoking mothers, and never smoking mothers were compared to assess the impact of maternal smoking behavior. Associations between maternal smoking behavior and 163 cord blood metabolites and associations between newborn head circumference and concentrations of smoking behavior related metabolites were analysed. Male newborns of smoking mothers had a reduced head circumference when compared with newborns from former smoking and never smoking mothers (p < 0.05). Using linear regression models corrected for established confounding factors, maternal smoking during pregnancy showed an independent association with head circumference (95% CI: -0.75 similar to -0.41 cm, p = 2.45 x 10(-11)). In a stepwise linear regression model corrected for known confounding factors of brain growth lyso-phosphatidylcholine 20:3 (95% CI: 6.68 similar to 39.88 cm, p = 4.62 x 10(-4)) was associated with head circumference in male offspring only. None of the metabolites were associated with head circumference of female newborns. In conclusion, maternal smoking during pregnancy impacted on male offspring's development including brain development. The smoking related metabolite lysophosphatidylcholine 20:3 was associated with head circumference of male offspring.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Maternal Smoking ; Head Circumference ; Male Offspring ; Biomarker ; Lyso-phosphatidylcholine 20:3; Birth-weight; Preterm Birth; Pregnancy; Exposure; Risk
ISSN (print) / ISBN
0960-0760
e-ISSN
0960-0760
Quellenangaben
Band: 199,
Artikelnummer: 105591
Verlag
Elsevier
Verlagsort
The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Molekulare Endokrinologie und Metabolismus (MEM)