PuSH - Publikationsserver des Helmholtz Zentrums München: Utility of gene expression studies in relation to radiation exposure and clinical outcomes: Thyroid cancer in the Ukrainian-American cohort and late health effects in a MAYAK worker cohort.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Abend, M.* ; Pfeiffer, R.M.* ; Port, M.* ; Hatch, M.* ; Bogdanova, T.* ; Tronko, M.D.* ; Mabuchi, K.* ; Azizova, T.* ; Unger, K. ; Braselmann, H. ; Ostheim, P.* ; Brenner, A.V.*

Utility of gene expression studies in relation to radiation exposure and clinical outcomes: Thyroid cancer in the Ukrainian-American cohort and late health effects in a MAYAK worker cohort.

Int. J. Radiat. Biol. 97, 12-18 (2020)

Postprint

DOI

PMC

	Open Access Green

Abstract
Metriken
Zusatzinfos

Purpose: We herein report on changes in gene expression after radiation exposure to iodine-131 from the Chernobyl accident in the Ukrainian-American thyroid cohort and to external gamma ray or internal plutonium exposure in the Mayak Production Association radiation workers. Materials and methods: Taking advantage of access to tissue samples from the thyroid cancer cases in the Ukrainian-American cohort, our group tried to identify candidate genes to discriminate spontaneously occurring thyroid cancers from thyroid cancers caused by radiation exposure. We also examined gene expression changes in normal and cancerous thyroid tissue in relation to iodine-131 dose separately. Gene expression changes in the peripheral blood of radiation exposed Mayak workers were examined to elucidate the dose-to-gene and gene-to-health (e.g. cardiovascular disease) relationships. Conclusions: Results of both projects are discussed under the aspect of dose-response relationships (dose-to-gene) and clinical outcome relationships (gene-to-effect) in light of how mechanistic data can be translated into actionable knowledge for radiation protection or clinical purposes.

Impact Factor

Scopus SNIP

Scopus
Cited By

Altmetric

2.368

0.752