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Razansky, D. ; Baeten, J. ; Ntziachristos, V.

Prediction of sensitivity thresholds in optoacoustic tomography.

Proc. SPIE 7564:75640L (2010)
Verlagsversion DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Since optoacoustic tomography is considered a high-resolution modality, determination of the absolute detection limit, as it relates to the sensitivity of biomarker detection is not straightforward. This is due to the fact that experimental determination of the sensitivity as a function of target size remains difficult since no established technique exists so far to reproducibly create very small targets containing well-defined concentrations of markers. We combine theoretical analysis with imaging results for large amounts of the marker and place the measured value on the appropriate parameter-dependent signal intensity curve. A performance estimate of the particular experimental system and the expected signal-to-noise-ratio for smaller amounts of markers can then be made.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Herausgeber Oraevsky, A. A.* ; Wang, L.V.*
Korrespondenzautor
Schlagwörter Bio-markers; Optoacoustics; Molecular contrast agents; Small animal imaging
ISSN (print) / ISBN 0277-786X
e-ISSN 1996-756X
Zeitschrift Proceedings of SPIE
Quellenangaben Band: 7564, Heft: , Seiten: , Artikelnummer: 75640L Supplement: ,
Verlag SPIE
Verlagsort Bellingham, WA
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)