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Sungnak, W.* ; Huang, N.* ; Bécavin, C.* ; Berg, M.* ; Queen, R.* ; Litvinukova, M.* ; Talavera-López, C.* ; Maatz, H.* ; Reichart, D.* ; Sampaziotis, F.* ; Worlock, K.B.* ; Yoshida, M.* ; Barnes, J.L.* ; HCA Lung Biological Network (Schiller, H. B. ; Theis, F.J.)

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.

Nat. Med. 26, 681–687 (2020)

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We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.

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