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Hu, C.* ; Meiners, S. ; Lukas, C. ; Stathopoulos, G.T. ; Chen, J.*

Role of exosomal microRNAs in lung cancer biology and clinical applications.

Cell Prolif. 53:e12828 (2020)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Exosomes, small extracellular vesicles ranging from 30 to 150 nm, are secreted by various cell types, including tumour cells. Recently, microRNAs (miRNAs) were identified to be encapsulated and hence protected from degradation within exosomes. These exosomal miRNAs can be horizontally transferred to target cells, in which they subsequently modulate biological processes. Increasing evidence indicates that exosomal miRNAs play a critical role in modifying the microenvironment of lung cancers, possibly facilitating progression, invasion, angiogenesis, metastasis and drug resistance. In this review, we summarize the novel findings on exosomal miRNA functions during lung cancer initiation and progression. In addition, we highlight their potential role and challenges as biomarkers in lung cancer diagnosis, prognosis and drug resistance and as therapeutic agents.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Biomarker ; Exosomal Mirnas ; Exosomes ; Lung Cancer ; Therapy; Epithelial-mesenchymal Transition; Extracellular Vesicles; Cells; Mirna; Cargo; Communication; Expression; Cisplatin; Plasma; Microvesicles
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 0008-8730
e-ISSN 1365-2184
Zeitschrift Cell Proliferation
Quellenangaben Band: 53, Heft: 6, Seiten: , Artikelnummer: e12828 Supplement: ,
Verlag Blackwell
Verlagsort Oxford [u.a.] ; Berlin ; Vienna
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-501600-004
G-501600-003
DOI 10.1111/cpr.12828
WOS ID WOS:000531415700001
Scopus ID 85084432058
PubMed ID 32391938
Erfassungsdatum 2020-05-13
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