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Giussani, A.* ; Lopez, M.A.* ; Romm, H.* ; Testa, A.* ; Ainsbury, E.A.* ; Degteva, M.* ; Della Monaca, S.* ; Etherington, G.* ; Fattibene, P.* ; Guclu, I.* ; Jaworska, A.* ; Lloyd, D.C.* ; Malatova, I.* ; McComish, S.* ; Melo, D.* ; Ośko, J.* ; Rojo, A.* ; Roch-Lefevre, S.* ; Roy, L.* ; Shishkina, E.* ; Sotnik, N.* ; Tolmachev, S.Y.* ; Wieser, A. ; Woda, C. ; Youngman, M.*

Eurados review of retrospective dosimetry techniques for internal exposures to ionising radiation and their applications.

Radiat. Environ. Biophys. 59, 357–387 (2020)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
This work presents an overview of the applications of retrospective dosimetry techniques in case of incorporation of radionuclides. The fact that internal exposures are characterized by a spatially inhomogeneous irradiation of the body, which is potentially prolonged over large periods and variable over time, is particularly problematic for biological and electron paramagnetic resonance (EPR) dosimetry methods when compared with external exposures. The paper gives initially specific information about internal dosimetry methods, the most common cytogenetic techniques used in biological dosimetry and EPR dosimetry applied to tooth enamel. Based on real-case scenarios, dose estimates obtained from bioassay data as well as with biological and/or EPR dosimetry are compared and critically discussed. In most of the scenarios presented, concomitant external exposures were responsible for the greater portion of the received dose. As no assay is available which can discriminate between radiation of different types and different LETs on the basis of the type of damage induced, it is not possible to infer from these studies specific conclusions valid for incorporated radionuclides alone. The biological dosimetry assays and EPR techniques proved to be most applicable in cases when the radionuclides are almost homogeneously distributed in the body. No compelling evidence was obtained in other cases of extremely inhomogeneous distribution. Retrospective dosimetry needs to be optimized and further developed in order to be able to deal with real exposure cases, where a mixture of both external and internal exposures will be encountered most of the times.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Biokinetics ; Biological Dosimetry ; Epr Dosimetry ; Internal Dosimetry ; Internal Exposures; Peripheral-blood Lymphocytes; Semipalatinsk Test-site; Thyroid-cancer Patients; Relative Biological Effectiveness; Stable Chromosome-aberrations; Tooth Enamel Dosimetry; Cytogenetic Follow-up; Nuclear Test-site; Epr Dosimetry; Techa River
ISSN (print) / ISBN 0301-634X
e-ISSN 1432-2099
Zeitschrift Radiation and Environmental Biophysics
Quellenangaben Band: 59, Heft: , Seiten: 357–387 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort One New York Plaza, Suite 4600, New York, Ny, United States
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Medicine (IRM)