PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Olsson, A.C.* ; Gustavsson, P.* ; Kromhout, H.* ; Peters, S.* ; Vermeulen, R.* ; Brüske, I. ; Pesch, B.* ; Siemiatycki, J.* ; Pintos, J.* ; Brüning, T* ; Cassidy, A.* ; Wichmann, H.-E. ; Consonni, D.* ; Landi, M.T.* ; Caporaso, N.* ; Plato, N.* ; Merletti, F.* ; Mirabelli, D.* ; Richiardi, L.* ; Jöckel, K.-H.* ; Ahrens, W.* ; Pohlabeln, H.* ; Lissowska, J.* ; Szeszenia-Dabrowska, N.* ; Zaridze, D.* ; Stücker, I.* ; Benhamou, S.* ; Bencko, V.* ; Foretova, L.* ; Janout, V.* ; Rudnai, P.* ; Fabianova, E.* ; Dumitru, RS.* ; Gross, IM.* ; Kendzia, B.* ; Forastiere, F.* ; Bueno-de-Mesquita, H.B.* ; Brennan, P.* ; Boffetta, P.* ; Straif, K.

Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada.

Am. J. Respir. Crit. Care Med. 183, 941-948 (2011)
Verlagsversion Forschungsdaten DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Rationale: Diesel motor exhaust is classified by the International Agency for Research on Cancer as probably carcinogenic to humans. The epidemiologic evidence is evaluated as limited because most studies lack adequate control for potential confounders and only a few studies have reported on exposure-response relationships. Objectives: Investigate lung cancer risk associated with occupational exposure to diesel motor exhaust, while controlling for potential confounders. Methods: The SYNERGY project pooled information on lifetime work histories and tobacco smoking from 13,304 cases and 16,282 controls from 11 case-control studies conducted in Europe and Canada. A general population job exposure matrix based on ISCO-68 occupational codes, assigning no, low, or high exposure to diesel motor exhaust, was applied to determine level of exposure. Measurements and Main Results: Odds ratios of lung cancer and 95% confidence intervals were estimated by unconditional logistic regression, adjusted for age, sex, study, ever-employment in an occupation with established lung cancer risk, cigarette pack-years, and time-since-quitting smoking. Cumulative diesel exposure was associated with an increased lung cancer risk highest quartile versus unexposed (odds ratio 1.31; 95% confidence interval, 1.19-1.43), and a significant exposure-response relationship (P value < 0.01). Corresponding effect estimates were similar in workers never employed in occupations with established lung cancer risk, and in women and never-smokers, although not statistically significant. Conclusions: Our results show a consistent association between occupational exposure to diesel motor exhaust and increased risk of lung cancer. This association is unlikely explained by bias or confounding, which we addressed by adjusted models and subgroup analyses.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
10.191
3.402
85
127
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter epidemiologic studies; lung neoplasm; occupational exposure; vehicle emissions
Sprache englisch
Veröffentlichungsjahr 2011
HGF-Berichtsjahr 2011
ISSN (print) / ISBN 1073-449X
e-ISSN 1535-4970
Zeitschrift American Journal of Respiratory and Critical Care Medicine
Quellenangaben Band: 183, Heft: 7, Seiten: 941-948 Artikelnummer: , Supplement: ,
Verlag American Thoracic Society
Verlagsort New York
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-001
PubMed ID 210370202103702021037020
DOI 10.1164/rccm.201006-0940OC
Erfassungsdatum 2011-05-10
[➜Korrektur melden]