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Bheda, P. ; Kirmizis, A.* ; Schneider, R.

The past determines the future: Sugar source history and transcriptional memory.

Curr. Genet. 66, 1029–1035 (2020)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Transcriptional reinduction memory is a phenomenon whereby cells "remember" their transcriptional response to a previous stimulus such that subsequent encounters with the same stimulus can result in altered gene expression kinetics. Chromatin structure is thought to play a role in certain transcriptional memory mechanisms, leading to questions as to whether and how memory can be actively maintained and inherited to progeny through cell division. Here we summarize efforts towards dissecting chromatin-based transcriptional memory inheritance ofGALgenes inSaccharomyces cerevisiae. We focus on methods and analyses ofGAL(as well asMALandINO) memory in single cells and discuss the challenges in unraveling the underlying mechanisms in yeast and higher eukaryotes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Transcriptional Memory ; Single-cell ; Inheritance ; Chromatin ; Gal ; Microfluidics ; History-dependent Behavior; Gene Loops
ISSN (print) / ISBN 0172-8083
e-ISSN 1432-0983
Zeitschrift Current Genetics
Quellenangaben Band: 66, Heft: , Seiten: 1029–1035 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort One New York Plaza, Suite 4600, New York, Ny, United States
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Functional Epigenetics (IFE)