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Brede, S.* ; Lutzke, B.* ; Albers, E.* ; Dalla-Man, C.* ; Cobelli, C.* ; Hallschmid, M. ; Klement, J.* ; Lehnert, H.*

Visual food cues decrease blood glucose and glucoregulatory hormones following an oral glucose tolerance test in normal-weight and obese men.

Physiol. Behav. 226:113071 (2020)
Postprint DOI
Open Access Green
Previous experiments of our group have demonstrated that preprandial processing of food cues attenuates postprandial blood glucose excursions. Here we systematically re-evaluated the glucose-lowering effect of visual food cues by submitting 40 healthy fasted men (20 normal-weight men, mean age 24.8 +/- 3.7 years, BMI 21.9 +/- 0.3 kg/m(2); 20 obese men, 26.8 +/- 4.2 years, 34.3 +/- 1.3 kg/m(2)) to an oral glucose tolerance test (OGTT) following exposure to pictures of high-calorie food items versus neutral items. OGTT-related changes in blood concentrations of glucose and relevant glucoregulatory hormones including GLP-1 were assessed and analyzed according to the oral minimal model. Independent of body weight, food-cue compared to neutral stimulus presentation reduced postprandial concentrations of glucose (p = 0.041), insulin (p = 0.026) and C-peptide (p = 0.007); accordingly, oral minimal model analyses yielded a food-cue induced decrease of dynamic-phase insulin secretion (p = 0.036). We also observed a trend towards lower GLP-1 levels directly after food cue stimulation in both body weight groups (p = 0.057), as well as a trend towards decreased heart rate (p = 0.093) and significantly decreased diastolic blood pressure (p = 0.019). While we did not detect indicators of an early rise in insulin levels in terms of a 'cephalic phase insulin response', our findings support the assumption that preprandial processing of food cues exerts marked effect on postprandial glucose regulation, with possible contributions of changes in GLP-1. The mechanisms linking food cue exposure and glucoregulatory improvements should be investigated in greater detail, to potentially open new treatment options for metabolic dysfunctions.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Visual Cues ; Food Pictures ; Ogtt ; Glucose Homeostasis ; Glp-1; Phase Insulin-secretion; Cephalic-phase; Minimal Model; Sensitivity; Glp-1; Taste
ISSN (print) / ISBN 0031-9384
e-ISSN 1873-507X
Zeitschrift Physiology & Behavior
Quellenangaben Band: 226, Heft: , Seiten: , Artikelnummer: 113071 Supplement: ,
Verlag Elsevier
Verlagsort The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Förderungen Helmholtz Alliance Imaging and Curing Environmental Metabolic Diseases (ICEMED), through the Initiative and Networking Fund of the Helmholtz Association
German Federal Ministry of Education and Research (BMBF Germany)
Deutsche Forschungsgemeinschaft