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Bohnacker, S. ; Hildenbrand, K.* ; Aschenbrenner, I.* ; Müller, S.I.* ; Esser-von Bieren, J. ; Feige, M.J.*

Influence of glycosylation on IL-12 family cytokine biogenesis and function.

Mol. Immunol. 126, 120-128 (2020)
Postprint DOI
Open Access Green
The interleukin 12 (IL-12) family of cytokines regulates T cell functions and is key for the orchestration of immune responses. Each heterodimeric IL-12 family member is a glycoprotein. However, the impact of glycosylation on biogenesis and function of the different family members has remained incompletely defined.Here, we identify glycosylation sites within human IL-12 family subunits that become modified upon secretion. Building on these insights, we show that glycosylation is dispensable for secretion of human IL-12 family cytokines except for IL-35. Furthermore, our data show that glycosylation differentially influences IL-12 family cytokine functionality, with IL-27 being most strongly affected.Taken together, our study provides a comprehensive analysis of how glycosylation affects biogenesis and function of a key human cytokine family and provides the basis for selectively modulating their secretion via targeting glycosylation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Interleukins ; Protein Glycosylation ; Protein Assembly ; Protein Secretion ; Immune Signaling; Cell Stimulatory Factor; Heterodimeric Cytokine; P40 Subunit; P35 Subunit; T-cells; Protein; Il-23; Receptor; Distinct; Form
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 0161-5890
e-ISSN 1872-9142
Zeitschrift Molecular Immunology
Quellenangaben Band: 126, Heft: , Seiten: 120-128 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Allergy
PSP-Element(e) G-554600-001
DOI 10.1016/j.molimm.2020.07.015
WOS ID WOS:000568666600016
Scopus ID 85089469908
Erfassungsdatum 2020-10-20
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