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Starke, S.* ; Leger, S.* ; Zwanenburg, A.* ; Leger, K.* ; Lohaus, F.* ; Linge, A.* ; Schreiber, A.* ; Kalinauskaite, G.* ; Tinhofer, I.* ; Guberina, N.* ; Guberina, M.* ; Balermpas, P.* ; Von der Grün, J.* ; Ganswindt, U. ; Belka, C. ; Peeken, J.C. ; Combs, S.E. ; Boeke, S.* ; Zips, D.* ; Richter, C.* ; Löck, S.*

2D and 3D convolutional neural networks for outcome modelling of locally advanced head and neck squamous cell carcinoma.

Sci. Rep. 10:15625 (2020)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
For treatment individualisation of patients with locally advanced head and neck squamous cell carcinoma (HNSCC) treated with primary radiochemotherapy, we explored the capabilities of different deep learning approaches for predicting loco-regional tumour control (LRC) from treatment-planning computed tomography images. Based on multicentre cohorts for exploration (206 patients) and independent validation (85 patients), multiple deep learning strategies including training of 3D- and 2D-convolutional neural networks (CNN) from scratch, transfer learning and extraction of deep autoencoder features were assessed and compared to a clinical model. Analyses were based on Cox proportional hazards regression and model performances were assessed by the concordance index (C-index) and the model’s ability to stratify patients based on predicted hazards of LRC. Among all models, an ensemble of 3D-CNNs achieved the best performance (C-index 0.31) with a significant association to LRC on the independent validation cohort. It performed better than the clinical model including the tumour volume (C-index 0.39). Significant differences in LRC were observed between patient groups at low or high risk of tumour recurrence as predicted by the model (p= 0.001). This 3D-CNN ensemble will be further evaluated in a currently ongoing prospective validation study once follow-up is complete.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 10, Heft: 1, Seiten: , Artikelnummer: 15625 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) CCG Personalized Radiotherapy in Head and Neck Cancer (KKG-KRT)
Institute of Radiation Medicine (IRM)
Förderungen Projekt DEAL