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Lund, J.V.* ; Kovacevic, D.* ; Schloter, M. ; Krauss-Etschmann, S.*

The role of the gut-lung axis in respiratory health.

Rolle der mikrobiellen Darm-Lungen-Achse für die Lungengesundheit.

Padiat. Praxis 93, 444-452 (2020)
The human microbiome is represented by a variety of microorganisms including bacteria, archaea, viruses and fungi that live on and inside our body. Most of them do not cause disease. In fact, microbes provide many important functions that humans did not develop themselves. They can digest food and supply host cells with nutrients, metabolize drugs, and activate and support the host's immune system. Knowledge about the microbiome has expanded with the development of novel culture-independent techniques, which revealed that healthy lungs also harbor diverse microbial communities and that variations in their composition can correlate with severity of lung diseases. Limited experimental evidence suggests an influence of the gut microbiome on respiratory health, involving different communication pathways, such as through the release of gut microbial metabolites, or via induced host metabolites or gut-lung immune cell trade. This implies that nutrition, by shaping the gut microbiome, could have an impact on respiratory diseases. However, this requires a precise mechanistic understanding how the gut microbiome affects microbial communities in the lungs and vice versa. Once better understood, this mechanism could be of particular interest in the future for the application of nutritive strategies in critical time window during the early childhood to improve lung health.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Bacterial Metabolites ; Gut-lung-axis ; Lung Diseases ; Microbiome
Sprache deutsch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 0030-9346
Zeitschrift Padiatrische Praxis
Quellenangaben Band: 93, Heft: 3, Seiten: 444-452 Artikelnummer: , Supplement: ,
Institut(e) Research Unit Comparative Microbiome Analysis (COMI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Environmental Sciences
PSP-Element(e) G-504700-001
Scopus ID 85091639872
Erfassungsdatum 2020-11-11
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