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Heger, L.* ; Hofer, T.P. ; Bigley, V.* ; de Vries, I.J.M.* ; Dalod, M.* ; Dudziak, D.* ; Ziegler-Heitbrock, L.*

Subsets of CD1c+DCs: Dendritic cell versus monocyte lineage.

Front. Immunol. 11:559166 (2020)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Currently three bona fide dendritic cell (DC) types are distinguished in human blood. Herein we focus on type 2 DCs (DC2s) and compare the three defining markers CD1c, CD172, and CD301. When using CD1c to define DC2s, a CD14(+)and a CD14(-)subset can be detected. The CD14(+)subset shares features with monocytes, and this includes substantially higher expression levels for CD64, CD115, CD163, and S100A8/9. We review the current knowledge of these CD1c(+)CD14(+)cells as compared to the CD1c(+)CD14(-)cells with respect to phenotype, function, transcriptomics, and ontogeny. Here, we discuss informative mutations, which suggest that two populations have different developmental requirements. In addition, we cover subsets of CD11c(+)CD8(-)DC2s in the mouse, where CLEC12A(+)ESAM(low)cells, as compared to the CLEC12A(-)ESAM(high)subset, also express higher levels of monocyte-associated markers CD14, CD3, and CD115. Finally, we summarize, for both man and mouse, the data on lower antigen presentation and higher cytokine production in the monocyte-marker expressing DC2 subset, which demonstrate that the DC2 subsets are also functionally distinct.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Dc2 ; Cd1c ; Cd172 ; Cd301 ; Cd14 ; Dendritic Cells ; Dc Subsets; Antigen Cross-presentation; Signal-regulatory Protein; Mononuclear Phagocytes; Molecular-cloning; Human Blood; In-vitro; Expression; Macrophage; Receptor; Lectin
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 1664-3224
e-ISSN 1664-3224
Zeitschrift Frontiers in Immunology
Quellenangaben Band: 11, Heft: , Seiten: , Artikelnummer: 559166 Supplement: ,
Verlag Frontiers
Verlagsort Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Virology (VIRO)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-502710-001
Förderungen Wellcome Trust
Erlanger Leistungsbezogene Anschubfinanzierung und Nachwuchsforderung (ELAN)
Interdisziplinares Zentrum fur Klinische Forschung
Agency national research (ANR)/German Research Foundation programBayresq.Net (Bavarian Ministry of Sciences)
German Research Foundation [Deutsche Forschungsgemeinschaft (DFG)]
DOI 10.3389/fimmu.2020.559166
WOS ID WOS:000579227200001
Scopus ID 85092749275
PubMed ID 33101275
Erfassungsdatum 2020-10-30
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