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Riba, A.* ; Hassani, K.* ; Walker, A. ; van Best, N.* ; von Zeschwitz, D.* ; Anslinger, T.* ; Sillner, N. ; Rosenhain, S.* ; Eibach, D.* ; Maiga-Ascofaré, O.* ; Rolle-Kampczyk, U.* ; Basic, M.* ; Binz, A.* ; Mocek, S.* ; Sodeik, B.* ; Bauerfeind, R.* ; Mohs, A.* ; Trautwein, C.* ; Kiessling, F.* ; May, J.* ; Klingenspor, M.* ; Gremse, F.* ; Schmitt-Kopplin, P. ; Bleich, A.* ; Torow, N.* ; von Bergen, M.* ; Hornef, M.W.*

Disturbed gut microbiota and bile homeostasis in Giardia-infected mice contributes to metabolic dysregulation and growth impairment.

Sci. Transl. Med. 12:eaay7019 (2020)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Although infection with the human enteropathogen Giardia lamblia causes self-limited diarrhea in adults, infant populations in endemic areas experience persistent pathogen carriage in the absence of diarrhea. The persistence of this protozoan parasite in infants has been associated with reduced weight gain and linear growth (height-for-age). The mechanisms that support persistent infection and determine the different disease outcomes in the infant host are incompletely understood. Using a neonatal mouse model of persistent G. lamblia infection, we demonstrate that G. lamblia induced bile secretion and used the bile constituent phosphatidylcholine as a substrate for parasite growth. In addition, we show that G. lamblia infection altered the enteric microbiota composition, leading to enhanced bile acid deconjugation and increased expression of fibroblast growth factor 15. This resulted in elevated energy expenditure and dysregulated lipid metabolism with reduced adipose tissue, body weight gain, and growth in the infected mice. Our results indicate that this enteropathogen's modulation of bile acid metabolism and lipid metabolism in the neonatal mouse host led to an altered body composition, suggesting how G. lamblia infection could contribute to growth restriction in infants in endemic areas.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Developing-countries; Diarrheal Disease; Lipid-metabolism; Lamblia; Duodenalis; Acid; Children; Responses; Infants; Impact
ISSN (print) / ISBN 1946-6234
e-ISSN 1946-6242
Zeitschrift Science Translational Medicine
Quellenangaben Band: 12, Heft: 565, Seiten: , Artikelnummer: eaay7019 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Analytical BioGeoChemistry (BGC)
Förderungen Niedersachsen-Research Network on Neuroinfectiology (N-RENNT)
Interdisciplinary Center for Clinical Research within the Faculty of Medicine at RWTH Aachen University
Cluster of Excellence RESIST, Hannover Medical School
German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig
Center for Systems Neuroscience (ZSN), Hannover, Germany
German Research Foundation (DFG)