PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Hils, M.* ; Wölbing, F.* ; Hilger, C.* ; Fischer, J.* ; Hoffard, N.* ; Biedermann, T.

The history of carbohydrates in type I allergy.

Front. Immunol. 11:586924 (2020)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Although first described decades ago, the relevance of carbohydrate specific antibodies as mediators of type I allergy had not been recognized until recently. Previously, allergen specific IgE antibodies binding to carbohydrate epitopes were considered to demonstrate a clinically irrelevant cross-reactivity. However, this changed following the discovery of type I allergies specifically mediated by oligosaccharide structures. Especially the emerging understanding of red meat allergy characterized by IgE directed to the oligosaccharide alpha-gal showed that carbohydrate-mediated reactions can result in life threatening systemic anaphylaxis which in contrast to former assumptions proves a high clinical relevance of some carbohydrate allergens. Within the scope of this review article, we illustrate the historical development of carbohydrate-allergen-research, reaching from only diagnostically relevant crossreactive-carbohydrate-determinants to clinically important antigens mediating type I allergy. Focusing on clinical and immunological features of the alpha-gal syndrome, we highlight the discovery of oligosaccharides as potentially highly immunogenic antigens and mediators of type I allergy, report what is known about the route of sensitization and the immunological mechanisms involved in sensitization and elicitation phase of allergic responses as well as currently available diagnostic and therapeutic tools. Finally, we briefly report on carbohydrates being involved in type I allergies different from alpha-gal.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
5.085
1.224
3
3
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Alpha-gal ; Carbohydrate ; Allergen ; Crossreactive Carbohydrate Determinants ; Glycolipid ; Glycoprotein ; Ige ; Type I Allergy; Red Meat Allergy; Killer T-cells; Natural Anti-gal; Alpha-gal; Ige-antibodies; Alpha-1,3-galactosyltransferase Gene; Cross-reactivity; Immunoglobulin-e; B-lymphocytes; N-glycans
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 1664-3224
e-ISSN 1664-3224
Zeitschrift Frontiers in Immunology
Quellenangaben Band: 11, Heft: , Seiten: , Artikelnummer: 586924 Supplement: ,
Verlag Frontiers
Verlagsort Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Allergy
PSP-Element(e) G-522200-001
Förderungen 395357507 - SFB1371 P06
SFB 1335 P17
BI696/10-1
SFB 824 B10
Deutsche Forschungsgemeinschaft (DFG, German Research foundation)
Luxembourg National Research Fund (FNR)
DOI 10.3389/fimmu.2020.586924
WOS ID WOS:000582363500001
Scopus ID 85094097789
PubMed ID 33163001
Erfassungsdatum 2020-11-16
[➜Korrektur melden]