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Litviňuková, M.* ; Talavera-López, C.* ; Maatz, H.* ; Reichart, D.* ; Worth, C.L.* ; Lindberg, E.L.* ; Kanda, M.* ; Polanski, K.* ; Heinig, M. ; Lee, M.* ; Nadelmann, E.R.* ; Roberts, K.* ; Tuck, L.* ; Fasouli, E.S.* ; DeLaughter, D.M.* ; McDonough, B.* ; Wakimoto, H.* ; Gorham, J.M.* ; Samari, S.* ; Mahbubani, K.T.* ; Saeb-Parsy, K.* ; Patone, G.* ; Boyle, J.J.* ; Zhang, H.* ; Viveiros, A.* ; Oudit, G.Y.* ; Bayraktar, O.A.* ; Seidman, J.G.* ; Seidman, C.E.* ; Noseda, M.* ; Hubner, N.* ; Teichmann, S.A.*

Cells of the adult human heart.

Nature 588, 466-472 (2020)
Postprint DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures. Furthermore, analyses of cell-to-cell interactions highlight different networks of macrophages, fibroblasts and cardiomyocytes between atria and ventricles that are distinct from those of skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a valuable reference for future studies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Resident Cardiac Macrophages; Smooth-muscle; Rna-seq; Endothelial-cells; Myocardial Injury; Adipose-tissue; Growth-factor; Expression; Protein; Gene
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 0028-0836
e-ISSN 1476-4687
Zeitschrift Nature
Quellenangaben Band: 588, Heft: 7838, Seiten: 466-472 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-553500-001
Förderungen NHLBI NIH HHS
Wellcome Trust
DOI 10.1038/s41586-020-2797-4
WOS ID WOS:000602624100033
WOS ID WOS:000592032200001
PubMed ID 32971526
Erfassungsdatum 2020-12-20
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