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Weidner, J.* ; Bartel, S.* ; Kılıç, A.* ; Zissler, U.M. ; Renz, H.* ; Schwarze, J.* ; Schmidt-Weber, C.B. ; Maes, T.* ; Rebane, A.* ; Krauss-Etschmann, S.* ; Radinger, M.*

Spotlight on microRNAs in allergy and asthma.

Allergy 76, 1661-1678 (2021)
Verlagsversion DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
In past 10 years, microRNAs (miRNAs) have gained scientific attention due to their importance in the pathophysiology of allergic diseases and their potential as biomarkers in liquid biopsies. They act as master post-transcriptional regulators that control most cellular processes. As one miRNA can target several mRNAs, often within the same pathway, dysregulated expression of miRNAs may alter particular cellular responses and contribute, or lead, to the development of various diseases. In this review, we give an overview of the current research on miRNAs in allergic diseases, including atopic dermatitis, allergic rhinitis, and asthma. Specifically, we discuss how individual miRNAs function in the regulation of immune responses in epithelial cells and specialized immune cells in response to different environmental factors and respiratory viruses. In addition, we review insights obtained from experiments with murine models of allergic airway and skin inflammation and offer an overview of studies focusing on miRNA discovery using profiling techniques and bioinformatic modeling of the network effect of multiple miRNAs. In conclusion, we highlight the importance of research into miRNA function in allergy and asthma to improve our knowledge of the molecular mechanisms involved in the pathogenesis of this heterogeneous group of diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Allergic Disease ; Asthma ; Experimental Models ; Microrna ; Pollution; Bronchial Epithelial-cells; Smooth-muscle-cells; Influenza-a Virus; Airway Eosinophilic Inflammation; Diesel Exhaust Particles; Tobacco-smoke Exposure; Innate Lymphoid-cells; Atopic-dermatitis; Chronic Rhinosinusitis; Circulating Micrornas
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Zeitschrift Allergy
Quellenangaben Band: 76, Heft: 6, Seiten: 1661-1678 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)
Förderungen European Academy of Allergy and Clinical Immunology