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Van Zuydam, N.R.* ; Ladenvall, C.* ; Voight, B.F.* ; Strawbridge, R.J.* ; Fernandez-Tajes, J.* ; Rayner, N.W.* ; Robertson, N.R.* ; Mahajan, A.* ; Vlachopoulou, E.* ; Goel, A.* ; Kleber, M.E.* ; Nelson, C.P.* ; Kwee, L.C.* ; Esko, T.* ; Mihailov, E.* ; Mägi, R.* ; Milani, L.* ; Fischer, K.* ; Kanoni, S.* ; Kumar, J.* ; Song, C.* ; Hartiala, J.A.* ; Pedersen, N.L.* ; Perola, M.* ; Gieger, C. ; Peters, A. ; Qu, L.* ; Willems, S.M.* ; Doney, A.S.F.* ; Morris, A.D.* ; Zheng, Y.* ; Sesti, G.* ; Hu, F.B.* ; Qi, L.* ; Laakso, M.* ; Thorsteinsdottir, U.* ; Grallert, H. ; van Duijn, C.M.* ; Reilly, M.P.* ; Ingelsson, E.* ; Deloukas, P.* ; Kathiresan, S.* ; Metspalu, A.* ; Shah, S.H.* ; Sinisalo, J.* ; Salomaa, V.* ; Hamsten, A.* ; Samani, N.J.* ; Marz, W.* ; Hazen, S.L.* ; Watkins, H.* ; Saleheen, D.* ; Colhoun, H.M.* ; Groop, L.* ; McCarthy, M.I.* ; SUMMIT Steering Committee; CARDIOGRAMplusC4D Steering Committee (Thorand, B.)

Genetic predisposition to coronary artery disease in type 2 diabetes mellitus.

Circ. Genom. Precis. Med. 13, 640-648 (2020)
Postprint Forschungsdaten DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Background: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). Methods: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D). Results: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background. Conclusions: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Blood Pressure ; Coronary Artery Disease ; Diabetes Mellitus ; Genome-wide Association Study ; Risk Factors; Genome-wide Association; Cardiovascular-disease; Common Variants; Glycemic Traits; Heart-disease; Loci; Pathways; Glucose; Risk; Insights
ISSN (print) / ISBN 2574-8300
e-ISSN 2574-8300
Zeitschrift Circulation Genomic and precision medicine
Quellenangaben Band: 13, Heft: 6, Seiten: 640-648 Artikelnummer: , Supplement: ,
Verlag Lippincott Williams & Wilkins
Verlagsort Philadelphia, Pa.
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology II (EPI2)
CCG Biomarker for the subclassification of T2DM (KKG-KDB)
CCG Nutrigenomics and Type 2 Diabetes (KKG-KDN)
Förderungen AtheroSysMed (Systems medicine of coronary heart disease)
British Heart Foundation Centre of Research Excellence at Oxford
ERC269045-Gene Target T2D grant
Estonian Research Council
Estonian Center of Genomics/Roadmap II
German Ministry of Education and Research
American Heart Association
Academy of Finland
European Union
Innovative Medicine Initiative (IMI)
Aarno Koskelo Foundation
Knut and Alice Wallenberg Foundation
Ministry for Higher Education
Stockholm County Council
Swedish Heart-Lung Foundation
Swedish Research Council
Torsten and Ragnar Soderberg Foundation
Wellcome Trust
Juho Vainio Foundation
Finnish Foundation for Cardiovascular research
Helsinki University Central Hospital special government funds
Juvenile Diabetes Research Foundation (JDRF)
National Institute of Diabetes and Digestive and Kidney diseases (NIDDK)
National Heart, Lung and Blood Institute (NLHBI)
Personalized diagnostics and treatment of high risk coronary artery disease patients (RiskyCAD)
Sigrid Juselius Foundation
Finnish Academy
Yrjo Jahnsson Foundation