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Hulstaert, E.* ; Morlion, A.* ; Avila Cobos, F.* ; Verniers, K.* ; Nuytens, J.* ; Vanden Eynde, E.* ; Yigit, N.* ; Anckaert, J.* ; Geerts, A.* ; Hindryckx, P.* ; Jacques, P.* ; Brusselle, G.* ; Bracke, K.R.* ; Maes, T.* ; Malfait, T.* ; Derveaux, T.* ; Ninclaus, V.* ; Van Cauwenbergh, C.* ; Roelens, K.* ; Roets, E.* ; Hemelsoet, D.* ; Tilleman, K.* ; Brochez, L.* ; Kuersten, S.* ; Simon, L.M.* ; Karg, S. ; Kautzky-Willers, A.* ; Leutner, M.* ; Nöhammer, C.* ; Slaby, O.* ; Prins, R.W.* ; Koster, J.* ; Lefever, S.* ; Schroth, G.P.* ; Vandesompele, J.* ; Mestdagh, P.*

Charting extracellular transcriptomes in the Human Biofluid RNA Atlas.

Cell Rep. 33:108552 (2020)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Extracellular RNAs present in biofluids have emerged as potential biomarkers for disease. Where most studies focus on blood-derived fluids, other biofluids may be more informative. We present an atlas of messenger, circular, and small RNA transcriptomes of a comprehensive collection of 20 human biofluids. By means of synthetic spike-in controls, we compare RNA content across biofluids, revealing a 10,000-fold difference in concentration. The circular RNA fraction is increased in most biofluids compared to tissues. Each biofluid transcriptome is enriched for RNA molecules derived from specific tissues and cell types. Our atlas enables an informed selection of the most relevant biofluid to monitor particular diseases. To verify the biomarker potential in these biofluids, four validation cohorts representing a broad spectrum of diseases were profiled, revealing numerous differential RNAs between case and control subjects. Spike-normalized data are publicly available in the R2 web portal for further exploration.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Biofluids ; Biomarker ; Cell-free Rna ; Circular Rna ; Extracellular Rna ; Liquid Biopsy ; Messenger Rna ; Rna Sequencing ; Small Rna; Messenger-rna; Circular Rna; Expression; Landscape; Microrna; Biomarkers
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Zeitschrift Cell Reports
Quellenangaben Band: 33, Heft: 13, Seiten: , Artikelnummer: 108552 Supplement: ,
Verlag Cell Press
Verlagsort 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)
Förderungen NCI (Exploring Cancer Medicine for Sarcoma and Rare Cancers)
Special Research Fund (BOF) scholarships of Ghent University
Ghent University
"Kom Op Tegen Kanker"(Stand Up To Cancer, the Flemish cancer society)
Czech Ministry of Health
NHGRI
Fund for Scientific Research Flanders (FWO)