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Laxy, M. ; Becker, J. ; Kähm, K. ; Holle, R. ; Peters, A. ; Thorand, B. ; Schwettmann, L. ; Karl, F.

Utility decrements associated with diabetes and related complications: Estimates from a population-based study in Germany.

Value Health 24, 274-280 (2021)
Verlagsversion DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
ISPOR–The Professional Society for Health Economics and Outcomes Research Objectives: Health utility decrement estimates for diabetes and complications are needed for parametrization of simulation models that aim to assess the cost-utility of diabetes prevention and care strategies. Thisstudy estimates health utility decrements associated with diabetes and cardiovascular and microvascular complications from a cross-sectional population-based German study. Methods: Data were obtained from the population based cross-sectional KORA (Cooperative Health Research in the Region of Augsburg) health questionnaire 2016 and comprised n = 1072 individuals with type 2 diabetes and n = 7879 individuals without diabetes. Health utility was assessed through the EQ-5D-5L. We used linear regression models with an interaction term between type 2 diabetes and cardiovascular and microvascular complications while adjusting for demographic and socio-economic factors and other comorbidities. Results: Type 2 diabetes (β = −0.028, standard error [SE] = 0.014), stroke (β = −0.070, SE = 0.010), cardiac arrhythmia (β = −0.031, SE = 0.006), heart failure (β = −0.073, SE = 0.009), coronary heart disease (β = −0.028, SE = 0.010), myocardial infarction (β = −0.020, SE = 0.011, estimates of main effec), and neuropathy (β = −0.067, SE = 0.020), diabetic foot (β = −0.042, SE = 0.030), nephropathy (β = −0.032, SE = 0.025), and blindness (β = −0.094, SE = 0.056, estimates of interaction terms) were negatively associated with health utility. The interaction term for diabetes x stroke (β = −0.052, SE = 0.021) showed that the utility decrement for stroke is significantly larger in people with type 2 diabetes than in people without diabetes. Conclusions: Diabetes, cardiovascular, and microvascular conditions are associated with significant health utility decrements. Utility decrements for some conditions differ between people with and without type 2 diabetes. These results are of high relevance for the parametrization of decision analytic simulation models and applied health economic evaluations in the field of prevention and management of diabetes in Germany.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Diabetes Complications ; Type 2 Diabetes ; Utility Decrements
ISSN (print) / ISBN 1098-3015
e-ISSN 1524-4733
Zeitschrift Value in Health
Quellenangaben Band: 24, Heft: 2, Seiten: 274-280 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort New York, NY
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Health Economics and Health Care Management (IGM)
Institute of Epidemiology II (EPI2)
Förderungen Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universitat, as part of LMUinnovativ
State of Bavaria
German Federal Ministry of Education and Research (BMBF)
Helmholtz Zentrum Munchen - German Research Center for Environmental Health