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Herker, E.* ; Vieyres, G.* ; Beller, M.* ; Krahmer, N. ; Bohnert, M.*

Lipid droplet contact sites in health and disease.

Trends Cell Biol. 31, 345-358 (2021)
Verlagsversion Article in press DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
After having been disregarded for a long time as inert fat drops, lipid droplets (LDs) are now recognized as ubiquitous cellular organelles with key functions in lipid biology and beyond. The identification of abundant LD contact sites, places at which LDs are physically attached to other organelles, has uncovered an unexpected level of communication between LDs and the rest of the cell. In recent years, many disease factors mutated in hereditary disorders have been recognized as LD contact site proteins. Furthermore, LD contact sites are dramatically rearranged in response to infections with intracellular pathogens, as well as under pathological metabolic conditions such as hepatic steatosis. Collectively, it is emerging that LD–organelle contacts are important players in development and progression of disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Bscl2 ; Cide ; Nafld ; Rab18 ; Viral Replication Organelle ; Vps13; Hepatitis-c Virus; Endoplasmic-reticulum; Insulin Sensitivity; Vldl Secretion; Protein; Seipin; Gene; Er; Perilipin; Rab18
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 0962-8924
e-ISSN 1879-3088
Quellenangaben Band: 31, Heft: 5, Seiten: 345-358 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Cambridge
Begutachtungsstatus Peer reviewed
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-501900-221
Förderungen Gerty Cori Programme, Medical Faculty, University of Munster, Germany
Helmholtz HGF project Aging and Metabolic Programming (AMPro)
DFG Emmy Noether Programme
University of Dsseldorf, Germany
LOEWE Center DRUID (Novel Drug Targets against Povertyrelated and Neglected Tropical Infectious Diseases)
Deutsche Forschungsgemeinschaft
Scopus ID 85100426318
PubMed ID 33546922
Erfassungsdatum 2021-04-14