Herker, E.* ; Vieyres, G.* ; Beller, M.* ; Krahmer, N. ; Bohnert, M.*
Lipid droplet contact sites in health and disease.
Trends Cell Biol. 31, 345-358 (2021)
After having been disregarded for a long time as inert fat drops, lipid droplets (LDs) are now recognized as ubiquitous cellular organelles with key functions in lipid biology and beyond. The identification of abundant LD contact sites, places at which LDs are physically attached to other organelles, has uncovered an unexpected level of communication between LDs and the rest of the cell. In recent years, many disease factors mutated in hereditary disorders have been recognized as LD contact site proteins. Furthermore, LD contact sites are dramatically rearranged in response to infections with intracellular pathogens, as well as under pathological metabolic conditions such as hepatic steatosis. Collectively, it is emerging that LD–organelle contacts are important players in development and progression of disease.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Typ der Hochschulschrift
Herausgeber
Schlagwörter
Bscl2 ; Cide ; Nafld ; Rab18 ; Viral Replication Organelle ; Vps13; Hepatitis-c Virus; Endoplasmic-reticulum; Insulin Sensitivity; Vldl Secretion; Protein; Seipin; Gene; Er; Perilipin; Rab18
Keywords plus
Sprache
englisch
Veröffentlichungsjahr
2021
Prepublished im Jahr
HGF-Berichtsjahr
2021
ISSN (print) / ISBN
0962-8924
e-ISSN
1879-3088
ISBN
Bandtitel
Konferenztitel
Konferzenzdatum
Konferenzort
Konferenzband
Quellenangaben
Band: 31,
Heft: 5,
Seiten: 345-358
Artikelnummer: ,
Supplement: ,
Reihe
Verlag
Elsevier
Verlagsort
Cambridge
Tag d. mündl. Prüfung
0000-00-00
Betreuer
Gutachter
Prüfer
Topic
Hochschule
Hochschulort
Fakultät
Veröffentlichungsdatum
0000-00-00
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Begutachtungsstatus
Peer reviewed
POF Topic(s)
90000 - German Center for Diabetes Research
Forschungsfeld(er)
Helmholtz Diabetes Center
PSP-Element(e)
G-501900-221
Förderungen
Gerty Cori Programme, Medical Faculty, University of Munster, Germany
Helmholtz HGF project Aging and Metabolic Programming (AMPro)
DFG Emmy Noether Programme
University of Dsseldorf, Germany
LOEWE Center DRUID (Novel Drug Targets against Povertyrelated and Neglected Tropical Infectious Diseases)
Deutsche Forschungsgemeinschaft
Copyright
Erfassungsdatum
2021-04-14