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Herker, E.* ; Vieyres, G.* ; Beller, M.* ; Krahmer, N. ; Bohnert, M.*

Lipid droplet contact sites in health and disease.

Trends Cell Biol. 31, 345-358 (2021)
Verlagsversion Article in press DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
After having been disregarded for a long time as inert fat drops, lipid droplets (LDs) are now recognized as ubiquitous cellular organelles with key functions in lipid biology and beyond. The identification of abundant LD contact sites, places at which LDs are physically attached to other organelles, has uncovered an unexpected level of communication between LDs and the rest of the cell. In recent years, many disease factors mutated in hereditary disorders have been recognized as LD contact site proteins. Furthermore, LD contact sites are dramatically rearranged in response to infections with intracellular pathogens, as well as under pathological metabolic conditions such as hepatic steatosis. Collectively, it is emerging that LD–organelle contacts are important players in development and progression of disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Bscl2 ; Cide ; Nafld ; Rab18 ; Viral Replication Organelle ; Vps13; Hepatitis-c Virus; Endoplasmic-reticulum; Insulin Sensitivity; Vldl Secretion; Protein; Seipin; Gene; Er; Perilipin; Rab18
ISSN (print) / ISBN 0962-8924
e-ISSN 1879-3088
Zeitschrift Trends in Cell Biology
Quellenangaben Band: 31, Heft: 5, Seiten: 345-358 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Cambridge
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
Förderungen Gerty Cori Programme, Medical Faculty, University of Munster, Germany
Helmholtz HGF project Aging and Metabolic Programming (AMPro)
DFG Emmy Noether Programme
University of Dsseldorf, Germany
LOEWE Center DRUID (Novel Drug Targets against Povertyrelated and Neglected Tropical Infectious Diseases)
Deutsche Forschungsgemeinschaft