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Zhao, Q.* ; Kress, S.* ; Markevych, I.* ; Berdel, D.* ; von Berg, A.* ; Gappa, M.* ; Koletzko, S.* ; Bauer, C.P.* ; Schulz, H. ; Standl, M. ; Heinrich, J.* ; Schikowski, T.*

Long-term air pollution exposure under EU limits and adolescents' lung function: Modifying effect of abnormal weight in GINIplus/LISA birth cohorts.

Chest 160, 249-258 (2021)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
BACKGROUND: Abnormal weights, e.g. Obesity, has shown strong modifying effect on the association between air pollution exposure and lung function impairment in adults. RESEARCH QUESTIONS: How may weight status modify the effects of long-term air pollution on adolescents' lung function, particularly in areas with pollution levels much lower than the current EU air quality standards? STUDY DESIGN AND METHODS: In this observational study, we investigated 2224 adolescents from the German GINIplus/LISA birth cohorts. Lung function was measured at age 15 years. Under, normal and over/obese weights were defined using percentiles of body mass index. Average concentrations of air pollution were modelled at residential addresses at four exposure windows between 0-15 years. Multivariable linear regression models were fitted by weight group on lung function with exposure at each window or cumulative exposure since birth. RESULTS: The median air pollution concentrations were half to two-thirds of the EU standards. Significant associations were observed only for individuals with under and over/obese weights. For example, per interquartile range increase in nitrogen dioxide at the 15th-year exposure window, the forced expiratory volume in one second (FEV1) declined by -2.9% [95% confidence interval (CI): -5.2 to -0.5%] for underweight group and -3.4% (95%CI: -5.4 to -1.2%) for over/obese weight group. Similarly, longer exposure to moderate-level air pollution since birth was significantly associated with lung function impairment for groups with abnormal weights. INTERPRETATION: Exposure to low-to-moderate levels of air pollution was associated with lung function impairment for adolescents with abnormal weights. Longer exposure aggravated the adverse effect. Whether there may be critical exposure window since birth warrants further exploration.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Adolescent ; Environmental Exposure ; Respiratory Health; Use Regression-models; Nutritional-status; Pm2.5 Absorbency; Chinese Children; Obesity; Areas; Health; No2; Associations; Pmcoarse
ISSN (print) / ISBN 0012-3692
e-ISSN 1931-3543
Zeitschrift Chest
Quellenangaben Band: 160, Heft: 1, Seiten: 249-258 Artikelnummer: , Supplement: ,
Verlag American College of Chest Physicians
Verlagsort Radarweg 29, 1043 Nx Amsterdam, Netherlands
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Förderungen European Regional Development Fund under the Smart Growth Operational Programme
Helmholtz Zentrum Munich
Marien-Hospital Wesel
LMU Munich
TU Munich
IUF-Leibniz Research Institute for Environmental Medicine
Federal Ministry for Environment
Helmholtz Centre for Environmental Research-UFZ, Leipzig
Marien-Hospital Wesel, Pediatric Practice
Bad Honnef
Commission of the European Communities
7th Framework Program (MeDALLproject)
Mead Johnson
Nestle companies
NeuroSmog: Determining the impact of air pollution on the developing brain
EU
Federal Ministry for Education, Science, Research and Technology and Helmholtz Zentrum Munich