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Multispectral optoacoustic tomography of peripheral arterial disease based on muscle hemoglobin gradients-a pilot clinical study.
Ann. Transl. Med. 9:36 (2021)
Background: Current imaging assessment of peripheral artery disease (PAD) relies on anatomical cross-sectional visualizations of the affected arteries. Multispectral optoacoustic tomography (MSOT) is a novel molecular imaging technique that provides direct and label-free visualizations of soft tissue perfusion and oxygenation. Methods: MSOT was prospectively assessed in a pilot trial in healthy volunteers (group n1=4, mean age 31, 50% male and group n3=4, mean age 37.3, 75% male) and patients with intermittent claudication (group n2=4, mean age 72, 75% male, PAD stage IIb). We conducted cuff-induced ischemia (group n1) and resting state measurements (groups n2 and n3) over the calf region. Spatially resolved mapping of oxygenated (HbO2), deoxygenated (Hb) and total (THb) hemoglobin, as well as oxygen saturation (SO2), were measured via hand-held hybrid MSOT-Ultrasound based purely on hemoglobin contrast. Results: Calf measurements in healthy volunteers revealed distinct dynamics for HbO2, Hb, THb and SO2 under cuff-induced ischemia. HbO2, THb and SO2 levels were significantly impaired in PAD patients compared to healthy volunteers (P<0.05 for all parameters). Revascularization led to significant improvements in HbO2 of the affected limb. Conclusions: Clinical MSOT allows for non-invasive, label-free and real-time imaging of muscle oxygenation in health and disease with implications for diagnostics and therapy assessment in PAD.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Medical Imaging ; Peripheral Arterial Disease ; Photoacoustic Techniques
ISSN (print) / ISBN
2305-5839
e-ISSN
2305-5847
Zeitschrift
Annals of Translational Medicine
Quellenangaben
Band: 9,
Heft: 1,
Artikelnummer: 36
Verlag
AME Publishing Company
Verlagsort
Flat-rm C 16f, Kings Wing Plaza 1, No 3 Kwan St, Shatin, Hong Kong 00000, Peoples R China
Nichtpatentliteratur
Publikationen
Förderungen
DZHK (German Centre for Cardiovascular Research)
Helmholtz Association of German Research Center, through the Initiative and Networking Fund, i3
Helmholtz Zentrum Munchen through Physician Scientists for Groundbreaking Projects
European Research Council (ERC) under the European Union
Helmholtz Association of German Research Center, through the Initiative and Networking Fund, i3
Helmholtz Zentrum Munchen through Physician Scientists for Groundbreaking Projects
European Research Council (ERC) under the European Union