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Mäki, J.M.* ; Kirjavainen, P.V.* ; Täubel, M.* ; Piippo-Savolainen, E.* ; Backman, K.* ; Hyvärinen, A.* ; Tuoresmäki, P.* ; Jayaprakash, B.* ; Heinrich, J. ; Herberth, G.* ; Standl, M. ; Pekkanen, J.* ; Karvonen, A.M.*

Associations between dog keeping and indoor dust microbiota.

Sci. Rep. 11:5341 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Living with dogs appears to protect against allergic diseases and airway infections, an effect possibly linked with immunomodulation by microbial exposures associated with dogs. The aim of this study was to characterize the influence of dog ownership on house dust microbiota composition. The bacterial and fungal microbiota was characterized with Illumina MiSeq sequencing from floor dust samples collected from homes in a Finnish rural-suburban (LUKAS2, N = 182) birth cohort, and the results were replicated in a German urban (LISA, N = 284) birth cohort. Human associated bacteria variable was created by summing up the relative abundances of five bacterial taxa. Bacterial richness, Shannon index and the relative abundances of seven bacterial genera, mostly within the phyla Proteobacteria and Firmicutes, were significantly higher in the dog than in the non-dog homes, whereas the relative abundance of human associated bacteria was lower. The results were largely replicated in LISA. Fungal microbiota richness and abundance of Leucosporidiella genus were higher in dog homes in LUKAS2 and the latter association replicated in LISA. Our study confirms that dog ownership is reproducibly associated with increased bacterial richness and diversity in house dust and identifies specific dog ownership-associated genera. Dogs appeared to have more limited influence on the fungal than bacterial indoor microbiota.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Endotoxin; Microorganisms; Determinants; Fungal; Life
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 11, Heft: 1, Seiten: , Artikelnummer: 5341 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-008
Förderungen Kuopio Area Respiratory Foundation
Juho Vainio Foundation
Yrjo Jahnsson Foundation
Foundation for Pediatric Research
EVO/VTR-funding
Paivikki and Sakari Sohlberg Foundation
Finnish Cultural Foundation
Finnish Institute for Health and Welfare, Finland
Federal Ministry for Education, Science, Research and Technology
Helmholtz Zentrum Munich, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Research Institute at Marien-Hospital Wesel
Academy of Finland
Academy of Finland as part of PROBIOM consortium
DOI 10.1038/s41598-021-84790-w
WOS ID WOS:000627411200017
Scopus ID 85102209620
PubMed ID 33674692
Erfassungsdatum 2021-04-20
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