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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Liver inflammation and hepatobiliary cancers.
Trends Cancer 7, 606-623 (2021)
Immune regulation has an important role in cancer development, particularly in organs with continuous exposure to environmental pathogens, such as the liver and gastrointestinal tract. Chronic liver inflammation can lead to the development of hepatobiliary cancers, namely hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA), or combined HCC (cHCC)-CCA. In this review, we discuss the link between oxidative stress and the hepatic immune compartments, as well as how these factors trigger hepatocyte damage, proliferation, and eventually cancer initiation and its sustainment. We further give an overview of new anticancer therapies based on immunomodulation.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Hcc ; Chcc-cca ; Icca ; Inflammation ; Oxidative Stress; Yes-associated Protein; Causes Nonalcoholic Steatohepatitis; Oxidative Dna-damage; Hepatocellular-carcinoma; Intrahepatic Cholangiocarcinoma; Hepatitis-c; Intestinal Microbiota; Apoptotic Bodies; United-states; Kupffer Cells
ISSN (print) / ISBN
2405-8033
e-ISSN
2405-8025
Zeitschrift
Trends in cancer
Quellenangaben
Band: 7,
Heft: 7,
Seiten: 606-623
Verlag
Elsevier
Verlagsort
Amsterdam
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Translational Metabolic Oncology (IDC-TMO)