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Peters, A. ; Nawrot, T.S.* ; Baccarelli, A.A.*

Hallmarks of environmental insults.

Cell 184, 1455-1468 (2021)
Postprint DOI PMC
Open Access Green
Environmental insults impair human health around the world. Contaminated air, water, soil, food, and occupational and household settings expose humans of all ages to a plethora of chemicals and environmental stressors. We propose eight hallmarks of environmental insults that jointly underpin the damaging impact of environmental exposures during the lifespan. Specifically, they include oxidative stress and inflammation, genomic alterations and mutations, epigenetic alterations, mitochondrial dysfunction, endocrine disruption, altered intercellular communication, altered microbiome communities, and impaired nervous system function. They provide a framework to understand why complex mixtures of environmental exposures induce severe health effects even at relatively modest concentrations.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 0092-8674
e-ISSN 1097-4172
Zeitschrift Cell
Quellenangaben Band: 184, Heft: 6, Seiten: 1455-1468 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Cambridge, Mass.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-010
Förderungen National Institute of Environmental Health Sciences, National Institutes of Health, USA
Flemish Research Fund, Belgium
European Union's Horizon 2020 research and innovation program
DOI 10.1016/j.cell.2021.01.043
WOS ID WOS:000630357400012
Scopus ID 85102562175
PubMed ID 33657411
Erfassungsdatum 2021-04-15
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